ArticleEngineering in life sciences2025
Mini Bubble Columns for Miniaturizing Scale-Down.
Article in Engineering in life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing.Engineering in life sciences · 2025Review
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2 authors.
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Abstract
The successful scale-up of biotechnological processes from laboratory to industrial scale is crucial for translating innovation to practice. Scale-down simulators have emerged as indispensable tools in this endeavor, enabling the evaluation of potential hosts' adaptability to the dynamic conditions encountered in large-scale fermenters. By simulating these real-world scenarios, scale-down simulators facilitate more accurate estimations of host productivity, thereby improving the process of selecting optimal strains for industrial production. Conventional scale-down systems for detailed intracellular analysis necessitate an elaborate setup comprising interconnected lab-scale reactors such as stirred tank reactors (STRs) and plug-flow reactors (PFRs), often proving time-consuming and resource-intensive. This work introduces a miniaturized bubble column reactor setup (60 mL working volume), enabling individual and parallel carbon-limited chemostat fermentations, offering a more efficient and streamlined approach. The industrially relevant organism
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