ArticleNeurotrauma reports2025
Correlations Between Morpho-structural Properties of the Brain and Cognitive and Motor Deficits in Individuals with Traumatic Brain Injury.
Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Traumatic brain injury (TBI) results in changes in brain networks followed by long-lasting behavioral and social impairments. This study explores the relationship between neurobehavioral as well as physical function deficits and structural changes in brain white matter (WM) and gray matter (GM) in individuals with TBI by evaluating morphometric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data. The structural MRI-based fractal analysis has emerged as a promising new approach to measure the morphology of the WM and GM. While DTI metrics reflect the microstructural properties of WM, the fractal dimension (FD) is regarded as a measure of morphometric complexity of the system, thus providing complementary information on the brain structure. This study included 10 individuals having moderate-to-severe TBI with balance/postural control deficits and 8 healthy controls. The network-based GM and WM morphologies were measured using FD and structural connectivity metrics, and fractional anisotropy (FA) was assessed using DTI in major WM tracts. The associations between brain structural (FA and FD) measures and a number of neuropsychological assessment and sensorimotor function outcomes were evaluated using partial least square correlation analysis. Our findings showed that the complexity in GM of default mode network, salience network, sensorimotor network, and frontoparietal network is positively correlated with the performance in cognitive and balance outcomes in patients with TBI. On the contrary, in DTI connectivity measures, only few regions including corona radiata, inferior longitudinal fasciculus, and middle cerebellar peduncle were strongly correlated with the behavioral outcomes in the TBI group. Our study suggests that the brain structure complexity measured by FD is a promising and complementary approach to DTI for potentially serving as a biomarker of cognitive and sensorimotor functions in TBI population.
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