Evidence map›Paper›PMID 39990626›Full record

ArticleBiological psychiatry global open science2025

Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well.

Maxie Liebscher, Silke White, Simon Hass, Anne Chocat, Florence Mezenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Anne-Laure Turpin, Natalie L Marchant and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maxie LiebscherGerman Center for Neurodegenerative Diseases, Dresden, Germany.
Silke WhiteGerman Center for Neurodegenerative Diseases, Dresden, Germany.
Simon HassGerman Center for Neurodegenerative Diseases, Dresden, Germany.
Anne ChocatNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Florence MezengeNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Brigitte LandeauNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Marion DelarueNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Oriane HébertNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Anne-Laure TurpinNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Natalie L MarchantDivision of Psychiatry, University College London, London, United Kingdom.
Gaël ChételatNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Olga KlimeckiTechnische Universität Dresden, Dresden, Germany.
Géraldine PoisnelNormandie University, UNICAEN, French Institute of Health and Medical Research, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders, NeuroPresage Team, GIP Cyceron, Caen, France.
Miranka WirthGerman Center for Neurodegenerative Diseases, Dresden, Germany.
Medit-Ageing Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Increased stress is a proposed risk factor for Alzheimer's disease (AD). We examined cross-sectional associations between circulating stress biomarkers and multimodal measures of brain health and cognition susceptible to AD in older adults and sex-specific subgroups. Methods: Baseline data from 132 cognitively unimpaired participants without depression (age, mean ± SD = 74.0 ± 4.0 years, women: Results: Higher epinephrine levels were associated (false discovery rate-corrected Conclusions: The current study demonstrates the involvement of circulating stress hormones, particularly epinephrine and cortisol, in greater resilience or vulnerability of brain health and cognitive indicators of susceptibility to AD in older adults. The identification of sex-specific patterns in these associations may inform the development of more effective and tailored interventions.

Indexed as

AgingAlzheimer’s diseaseHypothalamic-pituitary-adrenal (HPA)PreventionStressSympathetic-adrenal-medullary (SAM)

Identifiers

PMID39990626
PMCPMC11847304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.