Evidence map›Paper›PMID 39990551›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Human genomic regions of systemic interindividual epigenetic variation are implicated in neurodevelopmental and metabolic disorders.

Wen-Jou Chang, Uditha Maduranga, Chathura J Gunasekara, Alan Yang, Matthew Hirschtritt, Katrina Rodriguez, Cristian Coarfa, Goo Jun, Craig L Hanis, James M Flanagan and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wen-Jou ChangUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine; Houston, TX, USA.
Uditha MadurangaUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine; Houston, TX, USA.
Chathura J GunasekaraUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine; Houston, TX, USA.
Alan YangUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine; Houston, TX, USA.
Matthew HirschtrittDepartment of Psychiatry, Kaiser Permanente Oakland Medical Center; Oakland, CA, USA.
Katrina RodriguezDivision of Behavioral Health Services and Policy Research, New York State Psychiatric Institute; New York, NY, USA.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine; Houston, TX, USA.
Goo JunHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center; Houston, TX, USA.
Craig L HanisHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center; Houston, TX, USA.
James M FlanaganDivision of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London; London, UK.
Ivan P GorlovInstitute for Clinical and Translational Research, Baylor College of Medicine; Houston, TX, USA.
Christopher I AmosDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine; Houston, TX, USA.ORCID 0000-0002-8540-7023
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine; Los Angeles, CA, USA.
Catherine A SchaeferDivision of Research, Kaiser Permanente Northern California; Pleasanton, CA, USA.
Ezra S SusserMailman School of Public Health, Department of Epidemiology and Psychiatry, Columbia University; New York, NY, USA.
Robert A WaterlandUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine; Houston, TX, USA.

Funding

Systemic interindividual epigenetic variants in African Americans: Identification, characterization, and prospective associations with obesityR01DK129265 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WATERLAND, ROBERT A · 2021 to 2024
$2.2M
Unbiased identification and characterization of mouse metastable epiallelesR01DK125562 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WATERLAND, ROBERT A · 2020 to 2023
$1.8M
NIDDK NIH HHS R01 DK125562NIDDK NIH HHS R01 DK129265
6 · The paper itself

Abstract

Epigenome-wide association studies (EWAS) profile DNA methylation across the human genome to identify associations with diseases and exposures. Most employ Illumina methylation arrays; this platform, however, under-samples interindividual epigenetic variation. The systemic and stable nature of epigenetic variation at correlated regions of systemic interindividual variation (CoRSIVs) should be advantageous to EWAS. Here, we analyze 2,203 published EWAS to determine whether Illumina probes within CoRSIVs are over-represented in the literature. Enrichment of CoRSIV-overlapping probes was observed for most classes of disease, particularly for neurodevelopmental disorders and type 2 diabetes, indicating an opportunity to improve the power of EWAS by over 200- and over 100-fold, respectively. EWAS targeting all known CoRSIVs should accelerate discovery of associations between individual epigenetic variation and risk of disease.

Identifiers

PMID39990551
PMCPMC11844598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.