Evidence map›Paper›PMID 39990468›Full record

ArticlebioRxiv : the preprint server for biology2025

Cohesin drives chromatin scanning during the RAD51-mediated homology search.

Alberto Marin-Gonzalez, Adam T Rybczynski, Namrata M Nilavar, Daniel Nguyen, Violetta Karwacki-Neisius, Andrew G Li, Roger S Zou, Franklin J Avilés-Vázquez, Masato T Kanemaki, Ralph Scully and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alberto Marin-GonzalezHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-9076-1270
Adam T RybczynskiHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Namrata M NilavarDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6081-0513
Daniel NguyenDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Violetta Karwacki-NeisiusHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0009-0006-6273-9814
Andrew G LiDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Roger S ZouDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1338-6398
Franklin J Avilés-VázquezHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Masato T KanemakiDepartment of Chromosome Science, National Institute of Genetics, Mishima, Japan.ORCID 0000-0002-7657-1649
Ralph ScullyDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5064-0175
Taekjip HaHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2195-6258

Funding

Stalled replication fork repair in cancer predisposition and cancertherapyR35CA263813 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Ralph Scully · 2022 to 2026
$5.1M
Single Molecule Studies of Nucleic Acids RemodelingR35GM122569 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Taekjip Ha · 2017 to 2026
$3.5M
Chromatin Function During Transcription and DNA Repair at Single Molecule Resolutionin Living CellsU01DK127432 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HA, TAEKJIP, JOHNSON, MARGARET ELLEN · 2020 to 2024
$3.5M
NCI NIH HHS R35 CA263813NIDDK NIH HHS U01 DK127432NIGMS NIH HHS R35 GM122569
6 · The paper itself

Abstract

Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce

Identifiers

PMID39990468
PMCPMC11844420

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.