Evidence map›Paper›PMID 39990464›Full record

ArticlebioRxiv : the preprint server for biology2025

Exploiting attP landing sites and gypsy retrovirus insulators to identify and study viral suppressors of RNA silencing.

Adarsh K Gupta, Pratima R Chennuri, Raquel D Monfardini, Kevin M Myles

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Adarsh K GuptaDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-5038-2858
Pratima R ChennuriDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6737-7051
Raquel D MonfardiniDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-0922-8944
Kevin M MylesDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-9820-2502

Funding

Aedes antiviral RNAi pathwayR01AI141532 · NIAID · JOHNS HOPKINS UNIVERSITY · PI George Dimopoulos, KEVIN M MYLES · 2019 to 2026
$4.6M
NIAID NIH HHS R01 AI141532
6 · The paper itself

Abstract

RNA interference (RNAi) pathways are crucial for regulating viral infections in both animals and plants, acting as defense mechanisms that limit pathogen replication. This has led to the evolution of viral suppressors of RNA silencing (VSRs) across various plant and insect viruses, with potential analogs in arthropod-borne human pathogens. However, while functionally similar, VSRs often lack genetic conservation due to convergent evolution. Research on VSRs typically involves analyzing individual proteins expressed in host cells with secondary reporter constructs, but the lack of a standardized system can lead to inconsistent findings. Our study examined how genomic insertion sites affect VSR activity using a transgenic

Indexed as

AttPDrosophilaGypsyphiC31Reporter assayRNAiRNA interferenceRNA silencingTransgenicViral suppressor of RNA silencingVirusVSR

Identifiers

PMID39990464
PMCPMC11844480

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.