Evidence map›Paper›PMID 39990462›Full record

ArticlebioRxiv : the preprint server for biology2025

Fast-timescale hippocampal processes bridge between slowly unfurling neocortical states during memory search.

Sebastian Michelmann, Patricia Dugan, Werner Doyle, Daniel Friedman, Lucia Melloni, Camilla K Strauss, Sasha Devore, Adeen Flinker, Orrin Devinsky, Uri Hasson and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sebastian MichelmannDepartment of Psychology, New York University, New York, NY, USA.ORCID 0000-0002-5717-586X
Patricia DuganSchool of Medicine, New York University, New York, NY, USA.
Werner DoyleSchool of Medicine, New York University, New York, NY, USA.
Daniel FriedmanSchool of Medicine, New York University, New York, NY, USA.
Lucia MelloniSchool of Medicine, New York University, New York, NY, USA.
Camilla K StraussPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sasha DevoreSchool of Medicine, New York University, New York, NY, USA.
Adeen FlinkerSchool of Medicine, New York University, New York, NY, USA.
Orrin DevinskySchool of Medicine, New York University, New York, NY, USA.
Uri HassonPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Kenneth A NormanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-5887-9682

Funding

Neural dynamics supporting integration and recall over long timescales during natural continuous inputR01MH112357 · NIMH · PRINCETON UNIVERSITY · PI HASSON, URI, NORMAN, KENNETH A · 2017 to 2021
$2.5M
NIMH NIH HHS R01 MH112357
6 · The paper itself

Abstract

Prior behavioral work showed that event structure plays a key role in our ability to mentally search through memories of continuous naturalistic experience. We hypothesized that, neurally, this memory search process involves a division of labor between slowly unfurling neocortical states representing event knowledge and fast hippocampal-neocortical communication that supports retrieval of new information at transitions between events. To test this, we tracked slow neural state-patterns in a sample of ten patients undergoing intracranial electroencephalography as they viewed a movie and then searched their memories in a structured naturalistic interview. As patients answered questions ("after X, when does Y happen next?"), state-patterns from movie-viewing were reinstated in neocortex; during memory-search, states unfurled in a forward direction. Moments of state-transition were marked by low-frequency power decreases in cortex and preceded by power decreases in hippocampus that correlated with reinstatement. Connectivity-analysis revealed information-flow from hippocampus to cortex underpinning state-transitions. Together, these results support our hypothesis that fast hippocampal processes bridge between slow neocortical states during memory search.

Identifiers

PMID39990462
PMCPMC11844493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.