Evidence map›Paper›PMID 39990452›Full record

ArticlebioRxiv : the preprint server for biology2025

Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.

Shinwoo Kang, Minsu Abel Yang, Aubrey Bennett, Seungwoo Kang, Sang Wan Lee, Doo-Sup Choi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shinwoo KangDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, Minnesota 55905, USA.
Minsu Abel YangDepartment of Bio and Brain Engineering.ORCID 0000-0001-7685-1280
Aubrey BennettDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA.
Seungwoo KangDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912, USA.
Sang Wan LeeDepartment of Bio and Brain Engineering.ORCID 0000-0001-6266-9613
Doo-Sup ChoiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, Minnesota 55905, USA.

Funding

Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease.R01AG072898 · NIA · MAYO CLINIC ROCHESTER · PI CHOI, DOO-SUP, TRUSHINA, EUGENIA · 2020 to 2024
$2.0M
Astrocyte-Neuron Interaction in the Dorsal Striatum and Ethanol-Seeking Behaviors Diversity supplement - Matthew LopezR01AA029258 · NIAAA · MAYO CLINIC ROCHESTER · PI CHOI, DOO-SUP · 2021 to 2025
$1.8M
Astrocyte-neuron mechanisms of glutamatergic modulation in social novelty recognitionR01MH137204 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Seungwoo Kang · 2024 to 2026
$1.2M
Astrocytic dysfunction in anxiety and depression during alcohol withdrawalK01AA027773 · NIAAA · MAYO CLINIC ROCHESTER · PI KANG, SEUNGWOO · 2019 to 2022
$499k
NIAAA NIH HHS K01 AA027773NIAAA NIH HHS R01 AA029258NIA NIH HHS R01 AG072898NIMH NIH HHS R01 MH137204
6 · The paper itself

Abstract

Behavioral flexibility allows animals to adjust actions to changing environments. While the basal ganglia are critical for adaptation, the specific role of the external globus pallidus (GPe) is unclear. This study examined the contributions of two major GPe cell types-prototypic neurons projecting to the subthalamic nucleus (Proto

Indexed as

behavioral flexibilityexternal globus pallidusprototypic neuronreward-seeking behavior

Identifiers

PMID39990452
PMCPMC11844423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.