Evidence map›Paper›PMID 39990446›Full record

ArticlebioRxiv : the preprint server for biology2025

Inhibition of MAPK signaling suppresses cytomegalovirus reactivation in CD34

Vargab Baruah, Benjamin A Krishna, Michael C Kelly, Xu Qi, Christine M O'Connor

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Vargab BaruahInfection Biology; Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195 USA.ORCID 0000-0002-2882-7785
Benjamin A KrishnaInfection Biology; Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195 USA.ORCID 0000-0003-0919-2961
Michael C KellyInfection Biology; Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195 USA.
Xu QiInfection Biology; Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195 USA.
Christine M O'ConnorInfection Biology; Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195 USA.ORCID 0000-0003-4943-3774

Funding

Manipulation of host factors that promote HCMV latencyR01AI150931 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI O'CONNOR, CHRISTINE M · 2021 to 2025
$2.4M
HCMV GPCR functions during latency and reactivationR01AI153348 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI O'CONNOR, CHRISTINE M · 2021 to 2025
$2.2M
NIAID NIH HHS R01 AI150931NIAID NIH HHS R01 AI153348
6 · The paper itself

Abstract

Reactivation of latent human cytomegalovirus (CMV) can lead to severe complications in individuals with dysregulated immune systems. While antiviral therapies for CMV are approved, these compounds are limited by their toxicity and inability to specifically target the latent reservoir or prevent reactivation. Herein we show that CMV reactivation in Kasumi-3 cells, a CD34

Indexed as

CMVcytomegaloviruslatencyMAPKreactivationUS28

Identifiers

PMID39990446
PMCPMC11844548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.