Evidence map›Paper›PMID 39990432›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy.

Brooke A Brothers, Emily R Sechrest, Li Ma, Madyson Ashcraft, Tongju Guan, Robert J Barbera, Marion E Cahill, Lee M Shaw, Becky Chen, Wolfgang Baehr and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Brooke A BrothersDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506.
Emily R SechrestDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506.
Li MaDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506.
Madyson AshcraftDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506.
Tongju GuanDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506.
Robert J BarberaDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506.
Marion E CahillDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506.
Lee M ShawDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26506.
Becky ChenDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506.
Wolfgang BaehrDepartment of Ophthalmology, John A. Moran Eye Center, University of Utah Health Science Center, Salt Lake City, UT, 84132, USA.
Gangqing HuDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506.
Peter StoilovDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506.ORCID 0000-0003-1108-7271
Wen-Tao DengDepartment of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV 26506.ORCID 0000-0002-9357-0656

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Visvanathan Ramamurthy · 2022 to 2026
$13.9M
RETINAL PHOTORECEPTOR CYCLIC GMP PHOSPHODIESTERASER01EY008123 · NEI · UNIVERSITY OF UTAH · PI BAEHR, WOLFGANG · 1990 to 2019
$7.8M
Photoreceptor neuron specific alternative splicing of messenger RNAR01EY025536 · NEI · WEST VIRGINIA UNIVERSITY · PI RAMAMURTHY, VISVANATHAN, STOILOV, PETER · 2016 to 2023
$3.3M
Disease mechanisms of cone opsin mutants and treatment strategiesR01EY030056 · NEI · WEST VIRGINIA UNIVERSITY · PI DENG, WEN-TAO · 2019 to 2023
$1.9M
Recombinase-free conditional knock-in through alternative splicingR21EY036144 · NEI · WEST VIRGINIA UNIVERSITY · PI STOILOV, PETER · 2024 to 2025
$418k
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY008123NEI NIH HHS R01 EY025536NEI NIH HHS R01 EY030056NEI NIH HHS R21 EY036144NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM144230NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Blue cone monochromacy (BCM) is an X-linked retinal disorder caused by mutations in the

Indexed as

AAVblue cone monochromacyC203R cone opsincone dystrophycone opsingene therapytherapeutic window

Identifiers

PMID39990432
PMCPMC11844467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.