Evidence map›Paper›PMID 39990396›Full record

ArticlebioRxiv : the preprint server for biology2025

Defects in nephrogenesis result in an expansion of the

Michael G Michalopulos, Yan Liu, Dinesh Ravindra Raju, John T Lafin, Yanru Ma, Dhruv Gaur, Sadiksha Khadka, Chao Xing, Andrew P McMahon, Thomas J Carroll and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michael G MichalopulosDepartment of Pediatrics, Division of Pediatric Nephrology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Yan LiuEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dinesh Ravindra RajuEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John T LafinDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yanru MaLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dhruv GaurMidwestern University, Chicago College of Osteopathic Medicine, Chicago, IL, USA.
Sadiksha KhadkaDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chao XingDepartment of Bioinformatics and O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Thomas J CarrollDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Keri A DrakeDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9355-5202

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Application of Progenitor Niche Signals to Ex Vivo NephrogenesisRC2DK125960 · NIDDK · ROGOSIN INSTITUTE · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2021 to 2025
$7.4M
Cell Interactions in Development of the Mammalian KidneyR37DK054364 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2008 to 2017
$7.0M
CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEYR01DK054364 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 1998 to 2022
$6.9M
The Role of Renal Interstitium in Kidney DevelopmentR01DK127634 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CARROLL, THOMAS JOSEPH, PARK, JOO-SEOP · 2021 to 2024
$2.8M
Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidneyK08DK131258 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DRAKE, KERI ANNE · 2022 to 2024
$502k
NIDDK NIH HHS K08 DK131258NIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK054364NIDDK NIH HHS R01 DK127634NIDDK NIH HHS R37 DK054364NIDDK NIH HHS RC2 DK125960
6 · The paper itself

Abstract

Reciprocal signaling interactions coordinate multiple aspects of kidney development. While signals from the stroma have been shown to regulate nephron progenitor cell (NPC) differentiation, much less is known about regulation of the stromal progenitor population. Here, we demonstrate that disruption of the NPC lineage via loss of

Indexed as

crosstalknephron progenitor cellsstromal progenitor cellsWilms tumor 1 (Wt1)Wnt4

Identifiers

PMID39990396
PMCPMC11844377

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.