Evidence map›Paper›PMID 39990386›Full record

ArticlebioRxiv : the preprint server for biology2025

p63 co-opts the skin Krt8-to-Krt5 transition for enamel organ development.

Qinghuang Tang, Jung-Mi Lee, Liwen Li, Chunmiao Cai, Hunmin Jung, Hyuk-Jae Edward Kwon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qinghuang TangDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.ORCID 0000-0002-9436-8628
Jung-Mi LeeDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.ORCID 0000-0003-1231-582X
Liwen LiDepartment of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Chunmiao CaiDepartment of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3692-5120
Hunmin JungDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
Hyuk-Jae Edward KwonDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.ORCID 0000-0001-6538-6045

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Institutional Career DevelopmentKL2TR001413 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2015 to 2024
$4.2M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
Genomic and functional investigations of the transcriptional regulatory network of tooth enamel developmentR01DE033085 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Hyuk Jae Edward Kwon · 2023 to 2026
$2.5M
Epigenetic regulatory roles of Mll4 in palate developmentR03DE030985 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KWON, HYUK JAE EDWARD · 2021 to 2022
$319k
NCATS NIH HHS KL2 TR001413NCATS NIH HHS UL1 TR001412NIDCR NIH HHS R01 DE033085NIDCR NIH HHS R03 DE030985NIDCR NIH HHS T32 DE023526
6 · The paper itself

Abstract

Tooth enamel, the hardest vertebrate tissue, is crucial for mastication and dental protection. Its formation depends on the enamel organ (EO), a specialized epithelial structure derived from oral epithelium. How uniform oral epithelium differentiates into diverse EO cell types remains unclear. While

Indexed as

ATAC-seqenamel organ developmentKrt8-to-Krt5 transitionp63scRNA-seq

Identifiers

PMID39990386
PMCPMC11844444

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.