Evidence map›Paper›PMID 39990338›Full record

ArticlebioRxiv : the preprint server for biology2025

Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade.

Colin J Raposo, Patrick K Yan, Andy Y Chen, Saba Majidi, Kamir J Hiam-Galvez, Ansuman T Satpathy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Colin J RaposoDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5230-7931
Patrick K YanDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6124-1615
Andy Y ChenDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5018-355X
Saba MajidiDepartment of Pathology, Stanford University, Stanford, CA, USA.
Kamir J Hiam-GalvezDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1956-0257
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5167-537X

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
4DN Interrogation of T Cell Exhaustion in CancerU01CA260852 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2020 to 2024
$2.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
30-parameter FACSymphony A3 flow cytometer for Shared Resource LabS10OD026831 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2019 to 2019
$510k
BD Canto II RUO CytometerS10RR027431 · NCRR · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2010 to 2010
$236k
NCI NIH HHS U01 CA260852NCRR NIH HHS S10 RR027431NIAID NIH HHS T32 AI007290NIH HHS S10 OD026831NIH HHS S10 OD028511
6 · The paper itself

Abstract

Immune checkpoint blockade can facilitate tumor clearance by T cells, resulting in long term patient survival. However, the capacity of exhausted CD8

Identifiers

PMID39990338
PMCPMC11844384

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.