ArticlebioRxiv : the preprint server for biology2025
Feedback and feedforward control are differentially delayed in cerebellar ataxia.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Damage to the cerebellum can cause ataxia, a condition associated with impaired movement coordination. Typically, coordinated movement relies on a combination of anticipatory mechanisms (specifically, feedforward control) and corrective mechanisms (embodied by feedback control). Here, we show that in 3D reaching in VR, ataxia preserves the visuomotor feedforward and feedback control structure compared to the control group. However, the ataxia group exhibits a small increase in feedback delay (~ 20 ms) and a substantial increase in feedforward delay (~ 70 ms) together with a reduced feedback gain (~ 25% lower). Our results suggest that the feedforward and feedback pathways remain largely intact in ataxia, but that time delay deficits and temoral discoordination amongst these control pathways may contribute to the disorder. We also find that providing a preview-analogous to driving on a clear night and seeing the road ahead vs. driving in the fog-improves tracking performance in the ataxia group, although the control group was significantly better able to exploit this preview information. Overall, our results indicate that the feedforward control and preview utilization are relatively well-preserved in individuals with cerebellar ataxia, and that preview could potentially be leveraged to enhance the feedforward performance of those with ataxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.