ReviewInternational journal of nanomedicine2025
Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Current state of bioceramic bone repair materials in immune regulation: a review.Frontiers of medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis, osteoarthritis, and fractures are bone-related disorders that have a huge impact on the quality of life and healthcare systems worldwide. Traditional treatments, including bone grafts, have their limitations, with bone grafts often being rejected by the immune system and infected, making new treatments necessary. Nanopillars based on synthetic polymers have been demonstrated to be promising tools for bone regeneration and repair, showing to emulate the extracellular matrix composition, stimulate osteoblast activity and induce osteointegration. In this review, nanopillars fabrication techniques, such as electrospinning, nanoimprint lithography and self-assembly, also the state of the art of nanopillars technology are presented. Their role in modulating cellular responses via both physical and biochemical means, to enhance mineralization and to stabilize implants is also discussed. Additionally, their applications in treating bone-related disorders, eg promotion of fracture healing, augmentation of dental or orthopedic implants, and improvement of bone tissue engineering are discussed in the review. Using these focuses, each section examines opportunities and challenges (eg optimizing fabrication processes, improving biocompatibility, and investigating the integration of nanopillars with upcoming therapies like gene and stem cell therapy) for the potential of nanopillar technology. Finally, this review points out the requirement of scalable fabrication techniques, long term biocompatibility studies and multifunctional therapeutic strategies to fully employ the therapeutic applications of nanopillars in clinical scenarios. This review seeks to consolidate current knowledge of synthetic polymer based nanopillars and identify future directions for their use in bone related disorders through a comprehensive synthetic polymer nanopillar review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.