ArticleFrontiers in aging neuroscience2025
Higher systemic immune-inflammation index is associated with increased risk of Parkinson's disease in adults: a nationwide population-based study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Baseline peripheral inflammatory profiles predict phenoconversion in prodromal Parkinson's disease: a longitudinal cohort study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Peripheral immunochemical considerations in Parkinson disease: sources, targets and crosstalk mechanisms.Journal of translational medicine · 2026Review
- Isotopically enrichedScientific reports · 2026Article
- Peripheral Inflammatory Biomarkers in Parkinson's Disease: Clinical Correlations and Stratification.Cellular and molecular neurobiology · 2026Article
- Systemic inflammatory index correlates with cerebral small vessel disease in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Can smoking history, peripheral inflammation, and nutritional status discriminate Parkinson's disease? Development and validation of a clinically accessible nomogram.Frontiers in aging neuroscience · 2026Article
- Multidimensional Characterization of Parkinson's Disease Subtypes Through Motor Neuron Excitability and Peripheral Immune Dynamics: Insights from F-Wave Modulation Metrics.Diagnostics (Basel, Switzerland) · 2025Article
- Association of product of platelet and neutrophil count with monoclonal gammopathy of undetermined significance: a cross-sectional analysis of the NHANES.Blood research · 2025Article
- Associations between eight anthropometric indices and Parkinson's disease: a nationwide population-based study.Frontiers in nutrition · 2025Article
- Correlation of systemic immune inflammation index and systemic inflammatory response index with the severity of Parkinson's disease.Frontiers in neurologyArticle
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5 authors.
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Abstract
Background: This study aimed to explore the association between a new inflammatory marker, systemic immune-inflammation index (SII), and the risk of Parkinson's disease (PD) in adult population. Methods: A cross-sectional design was used, participants were recruited from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020. Three logistic regression models were used to explore the association between SII and the risk of PD, and subgroup analysis and sensitivity analysis were used. In addition, the restricted cubic spline (RCS) was used to explore the dose-response relationship between SII and PD. Receiver operating characteristic (ROC) curves was used to explore the diagnostic value of SII for PD. Results: A total of 54,027 adults (mean age 35 years) were included in this study. The results of logistic regression showed that after adjusted for all covariates, compared with the Q1 group (lowest quartile in SII), the risk of PD in the Q3 group (OR = 1.82, 95%CI = 1.20-2.82, Conclusion: SII is positively correlated with the prevalence of PD in the adult population, and SII can help differentiate between PD and non-PD cases.
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