Evidence map›Paper›PMID 39990022›Full record

ArticleOxford medical case reports2025

Challenging diagnosis: unusual presentation of Unicentric Castleman disease-a case report.

Omran Khaled Janoud, Raya Ehsan Alok, Khozama Ali Amer, Rana Mohammad Awwad, Wessam Souliman, Ghuroub Alkhayer

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omran Khaled JanoudFaculty of Medicine, Damascus University, Damascus, Syria.ORCID https://orcid.org/0009-0003-4630-8393
Raya Ehsan AlokFaculty of Medicine, Damascus University, Damascus, Syria.
Khozama Ali AmerFaculty of Medicine, Damascus University, Damascus, Syria.
Rana Mohammad AwwadFaculty of Medicine, Damascus University, Damascus, Syria.
Wessam SoulimanFaculty of Medicine, Damascus University, Damascus, Syria.
Ghuroub AlkhayerFaculty of Medicine, Damascus University, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Castleman's Disease is an idiopathic rare lymphoproliferative disorder that is clinically Classified to multicentric to unicentric types. Only few cases were reported in children, with majority of them are unicentric and usually located in the mediastinum. We report a unique case of a 13-year-old boy who presented with a palpable enlarged mass in the left inguinal region without any constitutional symptoms. Surgical removal of this mass was essential to exclude worrying causes. Pathologic examination revealed proliferative changes consistent with Castleman's disease plasma cell type which is one of the rarest forms of the disease in children. To our knowledge, this case is the first reported case of Unicentric Castleman Disease (UCD) in the inguinal area. During a 12-month-period of follow-up, no additional lymph node enlargements or other symptoms were reported. In conclusion, any isolated lymph node enlargement wherever it is, especially in a child, should impose UCD as a possible differential diagnosis.

Indexed as

Castleman diseaseinguinal lymph nodesPediatricssurgeryUnicentric Castleman’s disease

Identifiers

PMID39990022
PMCPMC11845339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.