Evidence map›Paper›PMID 39989990›Full record

ArticleProceedings (Baylor University. Medical Center)2025

Pembrolizumab-induced thyroid storm.

Ewelina Niedzialkowska, Lark Steafo, Sam Alsabti, Alice Kim

Abstract readCase Reports
In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ewelina NiedzialkowskaDepartment of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.ORCID https://orcid.org/0009-0004-7811-9607
Lark SteafoDepartment of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Sam AlsabtiDepartment of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Alice KimDivision of Endocrinology, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) are novel treatment modalities that have revolutionized the field of oncology. Their widespread use in various cancers and prolonged survival of patients led to the identification of a wide range of side effects associated with the therapy, known as immune-related adverse effects (irAEs). IrAEs are presumed to arise from immunologic enhancement and frequently result in endocrine disorders. Thyroid dysfunction is not uncommon during therapy with pembrolizumab and affects up to 13% to 14% of patients. Thyroid storm associated with ICIs is extremely rare. We present a case of a 34-year-old woman with metastatic ovarian carcinoma who developed thyroid storm shortly after an addition of pembrolizumab.

Indexed as

Immune checkpoint inhibitorspembrolizumabthyroid storm

Identifiers

PMID39989990
PMCPMC11845056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.