Evidence map›Paper›PMID 39989977›Full record

ArticleResearch square2025

How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition.

Xuemin Chen, Liangrui Yao, Shanshan Ma, Xingyun Yuan, Yang Yang, Yuan Yuan, Yumei Liu, Lan Liu, Huaibin Wang, Wei Yang and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Xuemin ChenAnhui university.ORCID 0000-0002-1818-9206
Liangrui YaoAnhui university.
Shanshan MaAnhui university.
Xingyun YuanAnhui university.
Yang YangAnhui university.
Yuan YuanAnhui university.
Yumei LiuAnhui university.
Lan LiuNational Institutes of Health.
Huaibin WangNational Institutes of Health.
Wei YangNIH/NIDDK.ORCID 0000-0002-3591-2195
Martin GellertNational Institutes of Health 0000-0002-0832-4929.ORCID 0000-0002-0832-4929

Funding

The post-cleavage complex in V(D)J recombinationZ01DK036167 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GELLERT, MARTIN F. · 2007 to 2008
$1.1M
Structural and mechanistic studies of V(D)J recombinationZ01DK036147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YANG, WEI · 2007 to 2008
$601k
Intramural NIH HHS Z01 DK036147Intramural NIH HHS Z01 DK036167
6 · The paper itself

Abstract

The RAG1/2 recombinase, which initiates V(D)J recombination in jawed vertebrates, evolved from RNaseH-like transposases such as Transib and ProtoRAG

Indexed as

H3K4me3PHDRAGtarget DNAtransposition

Identifiers

PMID39989977
PMCPMC11844651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.