Evidence map›Paper›PMID 39989951›Full record

ArticleResearch square2025

Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells.

Yasuyo Harada, Takanori Sasaki, Kazushige Obata-Ninomiya, Takahiro Matsuyama, Satoshi Ueha, Shigeyuki Shichino, Takashi Watanabe, Wu Bin, Shuhei Ogawa, Sewon Ki and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yasuyo HaradaDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.
Takanori SasakiDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.
Kazushige Obata-NinomiyaBenaroya Research Institute, Center for Fundamental Immunology, 1201 Ninth Avenue, Seattle WA 98101-2795.
Takahiro MatsuyamaDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 1-35-1 Sakuragaoka, Kagoshima 890-0075, Japan.ORCID 0009-00095167-8579
Satoshi UehaDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.ORCID 0000-0002-3871-9921
Shigeyuki ShichinoDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.ORCID 0000-0002-1683-2448
Takashi WatanabeLaboratory for Integrative Genomics, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Wu BinDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.
Shuhei OgawaDivision of integrated research, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.
Sewon KiLaboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Yoshie SuzukiLaboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Hideki UenoDepartment of Immunology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.ORCID 0000-0001-7747-0738
Steven F ZieglerBenaroya Research Institute, Center for Fundamental Immunology, 1201 Ninth Avenue, Seattle WA 98101-2795.ORCID 0000-0003-0657-5529
Hiromasa InoueDepartment of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 1-35-1 Sakuragaoka, Kagoshima 890-0075, Japan.ORCID 0000-0001-8080-3812
Peter D BurrowsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-5752-5647
Kenneth MurphyDepartment of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3505-9630
Brian S KimKimberly and Eric J. Waldman Department of Dermatology, Mark Lebwohl Center for Neuroinflammation and Sensation, Marc and Jennifer Lipschultz Precision Immunology Institute, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.ORCID 0000-0002-8100-7161
Masato KuboDivision of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, 2669 Yamazaki, Noda-shi, Chiba 278-0022, Japan.ORCID 0000-0001-7867-3086

Funding

Neuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8M
Regulation of IgE and Atopic ItchR01AI167933 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CONROY, MICHELLE E, KIM, BRIAN · 2022 to 2025
$3.2M
Natural Killer Cell Regulation of Skin InflammationR01AR077007 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2021 to 2025
$2.5M
Developing an Objective and Quantifiable Measure of Itch Using Artificial Intelligence and Radio SignalsR01AR080392 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KATABI, DINA · 2022 to 2024
$642k
The Role of IL-33 in Chronic ItchR21AI167047 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIM, BRIAN · 2021 to 2022
$460k
NIAID NIH HHS R01 AI167933NIAID NIH HHS R21 AI167047NIAMS NIH HHS R01 AR070116NIAMS NIH HHS R01 AR077007NIAMS NIH HHS R01 AR080392
6 · The paper itself

Abstract

Cutaneous allergen sensitization (CAS) underlies atopic dermatitis (AD) and leads to various allergic symptoms, including food allergy and anaphylaxis. IL-13 expression by T follicular helper T (T

Identifiers

PMID39989951
PMCPMC11844645

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.