Evidence map›Paper›PMID 39989909›Full record

ArticleAdvanced functional materials2025

Synthetic photoresponsive hydrogels enable

Mark W Young, Colter E Oroke, Bruce E Kirkpatrick, Michael R Blatchley, Peter J Dempsey, Kristi S Anseth

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Nuclei sense complex tissue shape and direct intestinal stem cell fate.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark W YoungDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Colter E OrokeDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Michael R BlatchleyDepartment of Biomedical and Chemical Engineering, BioInspired Institute, Syracuse University, Syracuse, NY 13210, USA.
Peter J DempseySection of Developmental Biology, Department of Pediatrics, University of Colorado, Denver, CO 80204, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
Laser Scanning Confocal MicroscopeS10OD034320 · OD · UNIVERSITY OF COLORADO · PI DRAGAVON, JOSEPH · 2023 to 2023
$445k
NCI NIH HHS P30 CA046934NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK120921NIH HHS S10 OD034320
6 · The paper itself

Abstract

As a model of the intestinal epithelium, intestinal stem cells (ISCs) have been grown and differentiated as monolayers on materials where stochastic organization of the crypt and villi cells occurs. We developed an allyl sulfide crosslinked photoresponsive hydrogel with a shear modulus of 1.6 kPa and functionalized with GFOGER, Bm-binder peptide ligands for monolayer growth of ISCs. The allyl sulfide chemistry allowed

Indexed as

Allyl SulfideHydrogelIntestinal stem cell

Identifiers

PMID39989909
PMCPMC11844746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.