Evidence map›Paper›PMID 39989843›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2025

Anatomical Distribution of Polyps Is Different for Men and Women With Positive Stool Tests.

Joseph C Anderson, William M Hisey, Christina M Robinson, Paul J Limburg, Bonny L Kneedler, Lynn F Butterly

Abstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Are Colon Polyp Characteristics Really Different Between Men and Women?JGH open : an open access journal of gastroenterology and hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph C AndersonGeisel School of Medicine at Dartmouth Hanover New Hampshire USA.ORCID https://orcid.org/0000-0002-8066-6333
William M HiseyDepartment of Medicine Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Christina M RobinsonDepartment of Medicine Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center Lebanon New Hampshire USA.
Paul J LimburgExact Sciences Corporation Madison Wisconsin USA.
Bonny L KneedlerExact Sciences Corporation Madison Wisconsin USA.
Lynn F ButterlyGeisel School of Medicine at Dartmouth Hanover New Hampshire USA.

Funding

Optimizing colorectal cancer prevention: a multi-disciplinary, population-based investigation of serrated polyps using risk prediction and modelingR01CA243449 · NCI · DARTMOUTH-HITCHCOCK CLINIC · PI AMOS, CHRISTOPHER I., BUTTERLY, LYNN F · 2020 to 2024
$3.0M
NCCDPHP CDC HHS U58 DP003930NCI NIH HHS R01 CA243449
6 · The paper itself

Abstract

Background and Aim: Our goal was to inform endoscopist practice by exploring how the odds of advanced neoplasia in the right and left colon differ between men and women with and without prior positive stool tests. Methods: Our primary outcome was advanced lesions (advanced adenomas, advanced serrated polyps, and/or colorectal cancer) found during colonoscopy. We used logistic regression to compare adjusted outcome odds by colon location (left or right), patient sex, and screening cohort. Results: Stool-test+ patients had higher odds for advanced lesions than colonoscopy-only patients throughout the colon, regardless of sex. While colonoscopy-only men had significantly higher odds of advanced lesions in the right vs. left colon (OR: 1.87 [1.75-1.99]), the odds of advanced lesions in mt-sDNA+ and FIT+ men did not differ significantly by colon location. As a result, compared to colonoscopy-only men, the increase in advanced lesion odds in stool-test+ men is significantly lower in the right vs. left colon (mt-sDNA+: OR: 0.63 [0.44-0.90]; FIT+; OR: 0.50 [0.30-0.83]). In stool-test+ women there was no significant difference in the degree of increase in advanced lesion odds in the right vs. left colon. Conclusions: Positive stool tests are associated with increased left- and right-sided advanced polyp yield in men and women at colonoscopy. However, stool-test-positive men had a significantly higher increase of advanced lesions in the left colon, whereas we found no such differences in women.

Indexed as

coloncolonoscopystool based screening tests

Identifiers

PMID39989843
PMCPMC11843466

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.