Evidence map›Paper›PMID 39989785›Full record

ArticleACS omega2025

Doxycycline-Loaded pH-Sensitive Microparticles as a Potential Site-Specific Drug Delivery System against Periodontitis.

Ardiyah Nurul Fitri Marzaman, Ulfah Mahfufah, Nurul Fauziah, Fadhlil Ulum Ar Rahman, Nasyrah Hidayati, Rafikah Hasyim, Dian Setiawati, Syaiful Choiri, Nur Aisyah Nuzulia, Aqilah Fidya Madani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Chitosan from sea urchin (Journal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ardiyah Nurul Fitri MarzamanFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Ulfah MahfufahFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Nurul FauziahFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Fadhlil Ulum Ar RahmanDepartment of Oral Maxillofacial Radiology, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.
Nasyrah HidayatiDepartment of Orthodontic, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.
Rafikah HasyimDepartment of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.ORCID https://orcid.org/0000-0002-2715-0098
Dian SetiawatiDepartment of Periodontology, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.
Syaiful ChoiriFaculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta 57126, Indonesia.ORCID https://orcid.org/0000-0001-7750-6008
Nur Aisyah NuzuliaFaculty of Mathematics and Natural Sciences, Institute Pertanian Bogor, Bogor 16680, Indonesia.
Aqilah Fidya MadaniFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Maria MirDepartment of Pharmacy, Iqra University, Islamabad Campus 44000, Pakistan.
Andi Dian PermanaFaculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.ORCID https://orcid.org/0000-0003-2168-1688
Karima Qurnia MansjurDepartment of Orthodontic, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia.ORCID https://orcid.org/0000-0001-9132-1229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant obstacle to the healing process of periodontitis is the development of bacterial biofilms within the periodontal pockets. The efficacy of bacterial biofilm therapy is often hindered by the inadequate penetration of antibacterial agents and the nonspecific targeting of bacteria. This study proposes a novel strategy involving the utilization of pH-sensitive microparticles (MPs) of doxycycline (DOX) to enhance biofilm penetration and enable targeted delivery of DOX to infection sites associated with periodontitis. The MPs were developed using a double-emulsion technique with poly(d,l-lactide-

Identifiers

PMID39989785
PMCPMC11840606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.