Evidence map›Paper›PMID 39989738›Full record

ArticlePeerJ2025

Corona or hydrochloric acid modulates embryonic diapause in silkworms by activating different signaling pathways.

Yuli Zhang, Guizheng Zhang, Mangui Jiang, Pingyang Wang, Xia Wang, Qiuying Cui, Quan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuli ZhangGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Guizheng ZhangGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Mangui JiangGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Pingyang WangGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Xia WangGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Qiuying CuiGuangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericultural Research Institute, Nanning, Guangxi Zhuang Autonomous Region, China.
Quan SunChongqing University of Posts and Telecommunications, Chongqing Key Laboratory of Big Data for Bio Intelligence, School of Life Health Information Science and Engineering, Nan'an, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To adapt to environmental changes, diapausing silkworm eggs remain dormant during the early stages of embryonic development. Various methods have been used to terminate silkworm egg diapause and promote egg hatching. Methods: To elucidate the molecular mechanisms by which corona and other treatments terminate silkworm egg diapause, we collected eggs at 1, 6, and 20 h after treatments and sequenced their transcriptomes. Results: The results showed that both corona and hydrochloric acid (HCl) treatments effectively terminated diapause and promoted egg hatching, with corona treatment inducing faster hatching than HCl treatment. Differentially expressed gene (DEG) analysis revealed the presence of fewer DEGs at 1 h, with a marked increase observed at 6 and 20 h post treatment. Functional enrichment analysis showed that the FoxO signaling pathway was activated at 6 h, with more substantial gene expression changes observed after corona treatment. In addition, HCl treatment appeared to activate the heat shock protein and hormone-regulated pathways. Our study results provide a basis for further analysis of the molecular mechanisms underlying diapause termination in silkworm eggs.

Indexed as

BombyxDiapauseDiapause, InsectHydrochloric AcidSignal TransductionAnimalsGene Expression Regulation, DevelopmentalOvumTranscriptomeHydrochloric AcidCorona treatmentDiapauseFoxO signaling pathwayHydrochloric acid treatmentRNA sequencingSilkworm

Identifiers

PMID39989738
PMCPMC11847486

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.