Evidence map›Paper›PMID 39989723›Full record

ArticleNature. Mental health2024

Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia.

Ronald McGregor, Ming-Fung Wu, Thomas C Thannickal, Songlin Li, Jerome M Siegel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ronald McGregorNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Ming-Fung WuNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7591-8743
Thomas C ThannickalNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Songlin LiNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Jerome M SiegelNeuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-2898-0111

Funding

Role of hypocretin in opiate addiction and withdrawalR01DA034748 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIEGEL, JEROME M · 2014 to 2024
$6.3M
Environmental determinants of human sleep timing, duration and continuity: studies in hunter gatherersR01HL148574 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIEGEL, JEROME M · 2019 to 2023
$3.6M
Maintaining opioid analgesia and preventing addiction with hypocretin antagonismR01DA058639 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME M SIEGEL · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL148574NIDA NIH HHS R01 DA034748NIDA NIH HHS R01 DA058639
6 · The paper itself

Abstract

Heroin use disorder in humans and chronic opioid administration to mice result in an increase in the number and a decrease in the size of detected hypocretin (Hcrt, or orexin) neurons. Chronic morphine administration to mice increases Hcrt axonal projections to the ventral tegmental area (VTA), the level of tyrosine hydroxylase (TH) in VTA and the number of detected TH

Identifiers

PMID39989723
PMCPMC11845277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.