ReviewJournal of the Royal Society of New Zealand2025
Animal studies linking the vestibular system and memory: Aotearoa/New Zealand's contribution.
Review in Journal of the Royal Society of New Zealand, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Assessment of auditory and vestibular function and gene therapy in the Snell's waltzer mouse model of human deafness and balance dysfunction.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- Hearing and balance research in Aotearoa New Zealand: sound and stable foundations for the future.Journal of the Royal Society of New Zealand · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal studies of the mammalian vestibular system began at the University of Otago in 1987. From approximately 2000, these studies focused on the effects of vestibular lesions and stimulation, on spatial memory and the hippocampus. Our research has shown that, as well as the deficits in the vestibulo-ocular and vestibulo-spinal reflexes that occur following vestibular dysfunction, vestibular loss may also cause cognitive disorders, especially spatial memory deficits, some of which are related to the contribution of ascending vestibular pathways to the function of the limbic system and neocortex in regulating spatial orientation. In addition to behavioural demonstrations of spatial memory deficits, we have demonstrated that vestibular loss is associated with a variety of dysfunctional changes in the hippocampus, which may be responsible for the spatial memory deficits. These memory deficits are unlikely to be due to hearing loss, problems with motor control, oscillopsia or anxiety and depression. These animal studies have raised awareness of cognitive deficits associated with vestibular disorders and contributed to their recognition and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.