ReviewJournal of family medicine and primary care2025
Infertility and risk of ovarian cancer: A systematic review and meta analysis.
Review in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Liquid Biopsy-Based Metabolomics in Epithelial Ovarian Cancer: Challenges, Methodological Advances and Translational Considerations.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-modernization has increased infertility globally. Infertility can cause ovarian, breast, and endometrial cancers. Recent studies have shown that a substantial proportion of couples undergoing infertility treatment develop cancer. However, existing studies yielded inconsistent results. Therefore, we conducted a meta-analysis to determine whether infertility increases the risk of ovarian cancer. Our systematic review and meta-analysis intended to identify the association between ovarian cancer and infertility based on the existing research. In accordance with PRISMA guidelines, this review contains studies on infertility and ovarian cancer as an outcome measure among ovarian cancer groups and those not having cancer. Two authors independently retrieved the articles through electronic databases such as PubMed and Scopus. This review includes 25 studies published worldwide between 2001 and 2022. This systematic review has been registered with the International Prospective Registry of Systematic Reviews (PROSPERO) (CRD CRD42021288860). The systematic review included 25 articles, while the meta-analysis included four. In total, data from 84,49,557 participants in 25 studies were extracted (21 cohort studies and 4 case-control studies). The global prevalence of ovarian cancer among women with a history of infertility was 0.5%. The calculated OR of developing ovarian cancer as a result of infertility was 1.35 (95% CI: 0.92-1.97). The pooled odds ratio of developing ovarian cancer as a result of infertility drug use was 0.93 (95% CI: 0.94-2.46). Pooled effect was shown to be stable and reliable by cumulative meta-analysis. The current meta-analysis showed that women who used infertility drugs had a higher risk of developing OC than those having a history of infertility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.