Evidence map›Paper›PMID 39989420›Full record

ArticleBiomacromolecules2025

Programming Aliphatic Polyester Degradation by Engineered Bacterial Spores.

Ziyu Cui, Masamu Kawada, Yue Hui, Seunghyun Sim

Abstract read
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Immobilization of alginate C-5 epimerases usingApplied and environmental microbiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ziyu CuiDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92697, United States.ORCID 0009-0005-2175-7859
Masamu KawadaDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID 0000-0001-5016-6322
Yue HuiDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID 0000-0002-0354-0382
Seunghyun SimDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92697, United States.ORCID 0000-0002-4232-5917

Funding

Spatially Structured Synthetic Consortia of Microbes to Understand and Engineer Cells in 3D EnvironmentsR35GM150770 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seunghyun Sim · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150770
6 · The paper itself

Abstract

Enzymatic degradation of plastics is a sustainable approach to address the growing issue of plastic accumulation. Here, we demonstrate the degradation of aliphatic polyesters using enzyme-displaying bacterial spores and the fabrication of self-degradable spore-containing plastics. The degradation proceeds without nutrient-dependent spore germination into living cells. Engineered spores completely degrade aliphatic polyesters into small molecules, retain activity through multiple cycles, and regain full activity through germination and sporulation. We also found that the interplay between the glass transition temperature and melting temperature of polyester substrates affects heterogeneous biocatalytic degradation by engineered spores. Directly incorporating spores into polyesters results in robust materials that are completely degradable. Our study offers a straightforward and sustainable biocatalytic approach to plastic degradation.

Indexed as

PolyestersSpores, BacterialBiocatalysisBiodegradation, EnvironmentalPolyesters

Identifiers

PMID39989420
PMCPMC11927956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.