Evidence map›Paper›PMID 39989357›Full record

ReviewCirculation. Genomic and precision medicine2025

Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association.

Rohan Khera, Aarti H Asnani, Jacob Krive, Daniel Addison, Han Zhu, Alexi Vasbinder, Matthew R Fleming, Rima Arnaout, Pedram Razavi, Tochukwu M Okwuosa and 1 more

Abstract readReview
In one paragraph

Review in Circulation. Genomic and precision medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Risk-guided cardioprotection in cardio-oncology.Nature cardiovascular research · 2026
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  15. Research Priorities and Future Directions in Cardio-Oncology.Current treatment options in oncology · 2026
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  18. Integrated Cardio-oncology Service.Cardiac failure review · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rohan Khera
Aarti H Asnani
Jacob Krive
Daniel Addison
Han Zhu
Alexi Vasbinder
Matthew R Fleming
Rima Arnaout
Pedram Razavi
Tochukwu M Okwuosa
American Heart Association Cardio-Oncology and Data Science and Precision Medicine Committees of the Council on Clinical Cardiology and Council on Genomic and Precision Medicine; Council on Cardiovascular Radiology and Intervention; and Council on Cardiovascular and Stroke Nursing

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Toward efficient performance for deep learning on medical imagingR01HL150394 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rima Arnaout · 2020 to 2026
$6.2M
Novel patient biomarkers and mechanisms of TKI associated CardiotoxicityR01HL170038 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Addison · 2023 to 2026
$2.7M
Translating Personalized Inference from Randomized Clinical Trials to Real-World Cardiovascular CareR01HL167858 · NHLBI · YALE UNIVERSITY · PI Rohan Khera · 2024 to 2026
$2.3M
Investigating CXCR3 Blockade as Precision Therapy for Cardiac Sarcoidosis using Single-Cell Multi-omics and TCR PhenotypingR01HL174432 · NHLBI · STANFORD UNIVERSITY · PI Han Zhu · 2024 to 2026
$2.2M
Therapeutic Strategies to Mitigate Toxicities of Anthracycline-Based TherapeuticsR01HL168045 · NHLBI · OHIO STATE UNIVERSITY · PI Daniel Addison, Sharyn D Baker · 2024 to 2026
$2.2M
Evaluating and Improving Utilization of Evidence-Based Medical Therapy in Patients with Heart Failure using Automated Tools in the Electronic Health RecordK23HL153775 · NHLBI · YALE UNIVERSITY · PI KHERA, ROHAN · 2021 to 2025
$918k
Identification of Causal T-Cell Mechanisms in Immune Checkpoint Inhibitor Induced MyocarditisK08HL161405 · NHLBI · STANFORD UNIVERSITY · PI Han Zhu · 2022 to 2026
$880k
Early Detection and Mechanisms of Cancer Immunotherapy Associated CardiotoxicityK23HL155890 · NHLBI · OHIO STATE UNIVERSITY · PI ADDISON, DANIEL · 2021 to 2024
$663k
CXCL9/10 Macrophage Induced CXCR3+ T-cell Recruitment to the Heart Contributes to Immunotherapy MyocarditisR03HL173146 · NHLBI · STANFORD UNIVERSITY · PI ZHU, HAN · 2024 to 2025
$236k
NCI NIH HHS K12 CA090625NHLBI NIH HHS K08 HL161405NHLBI NIH HHS K23 HL153775NHLBI NIH HHS K23 HL155890NHLBI NIH HHS L30 HL149063NHLBI NIH HHS R01 HL150394NHLBI NIH HHS R01 HL167858NHLBI NIH HHS R01 HL168045NHLBI NIH HHS R01 HL170038NHLBI NIH HHS R01 HL174432NHLBI NIH HHS R03 HL173146
6 · The paper itself

Abstract

Artificial intelligence is poised to transform cardio-oncology by enabling personalized care for patients with cancer, who are at a heightened risk of cardiovascular disease due to both the disease and its treatments. The rising prevalence of cancer and the availability of multiple new therapeutic options has resulted in improved survival among patients with cancer and has expanded the scope of cardio-oncology to not only short-term but also long-term cardiovascular risks resulting from both cancer and its treatments. However, there is considerable heterogeneity in cardiovascular risk, driven by the nature of the malignancy as well as each individual's unique characteristics. The use of novel therapies, such as targeted therapies and immune checkpoint inhibitors, across multiple cancer groups has also broadened the populations among which cardiotoxicity has become an important consideration of therapy. Therefore, the ability to understand and personalize cardiovascular risk management in patients with cancer is a key target for artificial intelligence, which can deduce and respond to complex patterns within the data. These advances necessitate an overview of established biomarkers of risk, spanning advanced imaging, diagnostic testing, and multi-omics, the evidence supporting their use, and the proven and proposed role of artificial intelligence in refining this risk to attain greater precision in risk prediction and management in cardio-oncologic care.

Indexed as

Artificial IntelligenceCardiovascular DiseasesMedical OncologyNeoplasmsPrecision MedicineAmerican Heart AssociationCardio-OncologyCardiotoxicityHumansUnited StatesAHA Scientific Statementsartificial intelligencecardio-oncologyprecision medicine

Identifiers

PMID39989357
PMCPMC12316026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.