Evidence map›Paper›PMID 39989300›Full record

ArticleEuropean journal of immunology2025

Survival and Developmental Progression of Unselected Thymocytes in the Absence of the T-Cell Adaptor Gads.

Rose Shalah, Manal Marzouk, Enas Hallumi, Naama Klopstock, Deborah Yablonski

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rose ShalahTechnion-Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel.
Manal MarzoukTechnion-Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel.
Enas HallumiTechnion-Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel.
Naama KlopstockTechnion-Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel.
Deborah YablonskiTechnion-Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa, Israel.ORCID 0000-0003-2979-0440

Funding

Colleck Research FundIsrael Science Foundation 283/22Minerva Stiftung Center Programme on Cell IntelligenceRappaport Family Institute for Research in the Medical Sciences
6 · The paper itself

Abstract

Thymocyte β-selection and positive-selection depend on TCR signaling via the immune adaptors SLP-76 and LAT. Gads bridges the recruitment of SLP-76 to LAT, yet is not required for the maturation of single positive (SP) thymocytes. To illuminate this paradox, we performed tamoxifen-induced ablation of Gads (Gads

Indexed as

Adaptor Proteins, Signal TransducingThymocytesAnimalsApoptosisCell DifferentiationCell SurvivalMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionAdaptor Proteins, Signal TransducingMembrane ProteinsReceptors, Antigen, T-Celladaptor proteinsdeath by neglectTCR signalingthymic development

Identifiers

PMID39989300
PMCPMC11848708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.