Evidence map›Paper›PMID 39989216›Full record

ArticleCancer science2025

Loss of Tapasin in Tumors Potentiates T-Cell Recognition and Anti-Tumor Effects of Immune Checkpoint Blockade.

Keigo Moniwa, Serina Tokita, Toshiyuki Sumi, Hiroshi Saijo, Shintaro Sugita, Kotomi Arioka, Yoshihiko Hirohashi, Hirofumi Chiba, Takayuki Kanaseki, Toshihiko Torigoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keigo MoniwaDepartment of Pathology, Sapporo Medical University, Sapporo, Japan.
Serina TokitaDepartment of Pathology, Sapporo Medical University, Sapporo, Japan.
Toshiyuki SumiDepartment of Respiratory Medicine, Hakodate Goryoukaku Hospital, Hakodate, Japan.ORCID https://orcid.org/0000-0002-2540-5878
Hiroshi SaijoDepartment of Respiratory Medicine, Sapporo Minami-Sanjo Hospital, Sapporo, Japan.
Shintaro SugitaDepartment of Surgical Pathology, Sapporo Medical University, Sapporo, Japan.
Kotomi AriokaDepartment of Surgical Pathology, Hakodate Goryoukaku Hospital, Hakodate, Japan.
Yoshihiko HirohashiDepartment of Pathology, Sapporo Medical University, Sapporo, Japan.ORCID https://orcid.org/0000-0002-0608-3914
Hirofumi ChibaDepartment of Respiratory Medicine and Allergology, Sapporo Medical University, Sapporo, Japan.
Takayuki KanasekiDepartment of Pathology, Sapporo Medical University, Sapporo, Japan.ORCID https://orcid.org/0000-0001-7294-6880
Toshihiko TorigoeDepartment of Pathology, Sapporo Medical University, Sapporo, Japan.

Funding

Japan Agency for Medical Research and Development JP24ama221315Japan Agency for Medical Research and Development JP24ama221328Japan Society for the Promotion of Science 24K02252Japan Society for the Promotion of Science 24K10110Ministry of Education, Culture, Sports, Science and Technology JPMXP0723833150
6 · The paper itself

Abstract

Tumors can evade host immune surveillance by compromising the intracellular antigen processing machinery (APM), such as beta 2 macroglobulin (β2m) or the transporter associated with antigen processing (TAP). Defects in the APM generally result in the downregulation of surface MHC class I (MHC-I) levels. Here, we show that the downregulation of a component of the peptide loading complex (PLC), tapasin, in tumors conversely induces CD8

Indexed as

Carcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesColonic NeoplasmsImmune Checkpoint InhibitorsMembrane Transport ProteinsAnimalsAntigen Presentationbeta 2-MicroglobulinCell Line, TumorFemaleHistocompatibility Antigens Class IHumansInterferon-gammaLung NeoplasmsMiceMice, Inbred C57BLbeta 2-MicroglobulinHistocompatibility Antigens Class IImmune Checkpoint InhibitorsInterferon-gammaMembrane Transport Proteinstapasinantigen processingCD8+ T cellsimmune checkpoint blockadeNSCLCTapasin

Identifiers

PMID39989216
PMCPMC12044650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.