ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Design, Synthesis, and Biophysical Characterization of Pyridine Bis-Quinazoline Derivatives as Selective G-Quadruplex DNA Stabilizers.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Structure-Informed Design of Distinct Parallel G-Quadruplex Stabilizers for KRAS-Driven Cancer Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies.Molecular therapy. Nucleic acids · 2026Review
- Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures.RSC chemical biology · 2026Article
- G-Quadruplex Unwinding Molecular Mechanisms by Helicases and Their Applications.International journal of molecular sciences · 2026Review
- Revealing G4 Structures as Drug Targets: Exploring the Potential of Novel Therapeutic Agents.Research (Washington, D.C.) · 2026Review
- Design, Synthesis, and Biophysical Characterization of Pyridine Bis-Quinazoline Derivatives as Selective G-Quadruplex DNA Stabilizers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
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2 authors.
Funding
Abstract
Non-canonical G-quadruplex (G4) DNA structures play key roles in cellular regulation and are promising targets for cancer therapy. This study reports the design, synthesis, and biophysical evaluation of 15 novel pyridine bis-quinazoline derivatives for their ability to selectively bind and stabilize G4 DNA structures. The pyridine-bis-quinazoline central fragment was synthesized with various amine side chains via a 4-5 step sequence in high yields. Comprehensive analyses using different fluorescence resonance energy transfer (FRET) assays, fluorescence intercalator displacement (FID), circular dichroism (CD), and nuclear magnetic resonance (NMR) assays revealed strong G4 stabilization and selectivity over double-stranded DNA. The presence and composition of the aliphatic amine side chain proved critical and propylamine linkers exhibited superior performance, achieving ΔT
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