Evidence map›Paper›PMID 39989026›Full record

ArticleJournal of the American Chemical Society2025

Chemoproteomics-Enabled

Brittney Racioppo, Dany Pechalrieu, Daniel Abegg, Brendan Dwyer, Neal Thomas Ramseier, Ying S Hu, Alexander Adibekian

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery.Angewandte Chemie (International ed. in English) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brittney RacioppoDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.
Dany PechalrieuDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.
Daniel AbeggDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.
Brendan DwyerSkaggs Doctoral Program in the Chemical and Biological Sciences, Scripps Research, 10550 N Torrey Pines Road, La Jolla, California 92037, United States.
Neal Thomas RamseierDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.ORCID 0000-0001-8813-596X
Ying S HuDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.ORCID 0000-0002-3912-7063
Alexander AdibekianDepartment of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.ORCID 0000-0001-6453-0244

Funding

Ultrasensitive quantification of cytokine release from T cellsR35GM146786 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ying Samuel Hu · 2022 to 2026
$2.2M
Probing conformational changes by protein surface azidationR01GM145886 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ADIBEKIAN, ALEXANDER · 2022 to 2025
$1.6M
Mapping Dynamic Changes in Protein Interactome using Proximity Labeling with High Temporal ResolutionR61CA297953 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Alexander Adibekian, ANDREI V KARGINOV · 2025 to 2026
$610k
NCI NIH HHS R61 CA297953NIGMS NIH HHS R01 GM145886NIGMS NIH HHS R35 GM146786
6 · The paper itself

Abstract

Proteolysis targeting chimeras (PROTACs) represent powerful tools to modulate the activity of classically "undruggable" proteins, but their application has been limited to known ligands and a few select protein classes. Herein, we present our chemoproteomic strategy for simultaneous

Indexed as

MetallothioneinNeoplasmsProteolysisProteomicsCell Line, TumorHumansLigandsProteolysis Targeting ChimeraLigandsMetallothioneinMT2A protein, humanProteolysis Targeting Chimera

Identifiers

PMID39989026
PMCPMC12947296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.