Evidence map›Paper›PMID 39989009›Full record

ArticleCurrent neuropharmacology2025

Appraisal of the Neuroprotective Potentials of Isoeugenol Using

Bandar A Alyami, Zeeshan Ahmad, Mehreen Ghufran, Mater H Mahnashi, Abdul Sadiq, Muhammad Ayaz

Abstract read
In one paragraph

Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice-A Role Beyond Nrf2 Activation?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Cepharanthine InhibitsMicroorganisms · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bandar A AlyamiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.
Zeeshan AhmadDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan.
Mehreen GhufranDepartment of Pathology, MTI Bacha Khan Medical College, Mardan, KP, Pakistan.
Mater H MahnashiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.
Abdul SadiqDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan.
Muhammad AyazDepartment of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan.

Funding

deputy for research and innovation, Ministry of Education, Kingdom of Saudi Arabia NU/IFC/02//MRC/-/011
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a neurodegenerative condition that affects the elder population and is linked to behavioral instability and cognitive decline. Only a few drugs are approved for clinical management of AD. Volatile oils and their components exhibit diverse pharmacological potentials, including neuroprotective properties. The current study aimed to evaluate isoeugenol's neuroprotective potentials against cognitive impairments caused by scopolamine.

methodsStandard protocols were followed in the

resultsIn DPPH and ABTS assays, isoeugenol exhibited considerable efficacy against free radicals with IC

conclusionIsoeugenol offered considerable protection against scopolamine-induced memory deficits and improved the special memory of the rodents.

Indexed as

EugenolNeuroprotective AgentsAcetylcholinesteraseAmnesiaAnimalsAntioxidantsBiphenyl CompoundsButyrylcholinesteraseCholinesterase InhibitorsComputer SimulationMaleMaze LearningMolecular Docking SimulationRatsRats, WistarScopolamineAcetylcholinesteraseAntioxidantsBiphenyl CompoundsButyrylcholinesteraseCholinesterase InhibitorsEugenolisoeugenolNeuroprotective AgentsScopolamineAlzheimer’s diseaseAmnesiaCholinesteraseisoeugenolmolecular dockingoxidative stress.

Identifiers

PMID39989009
PMCPMC11808583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.