Evidence map›Paper›PMID 39988985›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

NAD

Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin and 10 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Nicotinamide Metabolism Constrains Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling.International journal of biological sciences · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Sirtuins in Women's Health.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Epigenetic regulation in gynecological cancers: a paradigm shift in immunotherapy strategies.Journal of experimental & clinical cancer research : CR · 2025
    Review
  19. Review
  20. NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xinyi LuAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Pingping JinAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Qianyun TangAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Min ZhouAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Hanjie XuAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Chen SuAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Lei WangWuxi Medical Center, Nanjing Medical University, Jiangsu, 214023, China.
Feng XuAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Min ZhaoAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Yongxiang YinAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Jinqiu ZhangAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Zhen JiaDepartment of Laboratory, Haidong Second People's Hospital, Haidong, 810699, China.
Xinrui PengAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Jie ZhouAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Lu WangAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Yan ChenAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Min WangWuxi Medical Center, Nanjing Medical University, Jiangsu, 214023, China.
Min YangMolecular Imaging Centre, Jiangsu Institute of Nuclear Medicine, Jiangsu, 214063, China.
Daozhen ChenAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Yu ChenAffiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.ORCID https://orcid.org/0000-0001-9420-1636

Funding

Jiangsu Province Graduate Research and Practice Innovation Plan Project KYCX23_1938Major scientific research project of Wuxi Municipal Health Commission Z202408National Natural Science Foundation of China 82473350Qinghai Province Key Research and Development and Transformation Plan Specific fund of Science and Technology Assistance to Qinghai 2022-QY-216
6 · The paper itself

Abstract

Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed death ligand 1(PD-1/PD-L1) axis showing promise but encountering resistance in a significant patient population. This resistance has driven a critical quest to uncover the underlying mechanisms. This study uncovers a novel metabolic axis involving the nicotinamide adenine dinucleotide (NAD

Indexed as

B7-H1 AntigenNADSirtuin 1Uterine Cervical NeoplasmsAcetylationCell Line, TumorCell NucleusFemaleHumansMetabolic ReprogrammingNicotinamide PhosphoribosyltransferaseB7-H1 AntigenCD274 protein, humanNADNicotinamide PhosphoribosyltransferaseSIRT1 protein, humanSirtuin 1acetyl‐proteomicscervical cancerimmunotherapy resistanceNAD+ metabolismPD‐L1, SIRT1

Identifiers

PMID39988985
PMCPMC12005810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.