Evidence map›Paper›PMID 39988830›Full record

ArticleACS chemical neuroscience2025

Purinergic Receptor P2Y1 Modulates Catecholamine Signaling in Murine Mesenteric Lymph Nodes.

Alexandra K Brooke, Sarbeshwar Ojha, Daniel P Murrow, Ashley E Ross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra K BrookeDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221. United States.
Sarbeshwar OjhaDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221. United States.ORCID 0000-0001-5767-6755
Daniel P MurrowDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221. United States.
Ashley E RossDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221. United States.ORCID 0000-0003-2456-3636

Funding

Monitoring neurochemical signaling dynamics in the lymph nodeR01AI151552 · NIAID · UNIVERSITY OF CINCINNATI · PI ROSS, ASHLEY E · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI151552
6 · The paper itself

Abstract

Neuroimmune communication is crucial for the body's response to physiological challenges, homeostasis, and immune stress response. Adrenergic and purinergic neurotransmission in the sympathetic nervous system is vital for this communication. This study achieves the first co-detection of adenine-based purines and catecholamines in mesenteric lymph nodes via fast-scan cyclic voltammetry. Additionally, we reveal that manipulating an ATP receptor can impact catecholamine signaling in the lymph node for the first time. The G-protein-coupled receptor P2Y1, which controls intracellular Ca

Indexed as

CatecholaminesLymph NodesReceptors, Purinergic P2Y1Signal TransductionAdenosine DiphosphateAdenosine TriphosphateAnimalsMaleMesenteryMiceMice, Inbred C57BLNorepinephrinePurinergic P2Y Receptor AntagonistsAdenosine DiphosphateAdenosine TriphosphateCatecholaminesN(6)-methyl-2'-deoxyadenosine 3',5'-diphosphateNorepinephrinePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y1CatecholaminesFast-Scan Cyclic VoltammetryLymph NodesP2Y1Purine

Identifiers

PMID39988830
PMCPMC12248414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.