Evidence map›Paper›PMID 39988786›Full record

ArticleExperimental physiology2025

Two-tone suppression between the ultrasounds above and within the hearing range in mice.

Noriko Nagase, Hirokazu Kousaki, Bakushi Ogawa, Kazuhiro Horii, Iori Niitsu Morimoto, Chikara Abe, Takenori Ogawa, Fumiaki Nin

Abstract read
In one paragraph

Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noriko NagaseDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Hirokazu KousakiDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Bakushi OgawaDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Kazuhiro HoriiDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Iori Niitsu MorimotoDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Chikara AbeDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Takenori OgawaDivision of Sensorimotor Medicine, Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Gifu University, Gifu, Japan.
Fumiaki NinDivision of Biological Principles, Department of Physiology and Biophysics, Graduate School of Medicine, Gifu University, Gifu, Japan.ORCID https://orcid.org/0000-0002-0408-7540

Funding

Ministry of Education, Culture, Sports, Science and Technology (MEXT) 22K15364Ministry of Education, Culture, Sports, Science and Technology (MEXT) 24K02598Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering (Nakatani Foundation) 2022S107Ogawa Memorial FoundationSuzuken Memorial Foundation (SMF) 23-022Takeda Science Foundation (TSF) 2024047242Terumo Life Science Foundation 24-III1047the Naito FoundationToray Industries, Inc. | Toray Science Foundation (TSF) 20-6109
6 · The paper itself

Abstract

Hearing range differs among various species. Ultrasound, which is audible to microbats and dolphins, is inaudible to humans through air conduction. However, it can create an auditory sensation when the stimulation is transmitted through the temporal bone. This phenomenon is known as ultrasonic hearing - sounds at frequencies exceeding the normal hearing range participate in audition. Mice are among the animals that possess one of the highest upper limits of the hearing range. Although ultrasonic hearing has been experimentally demonstrated in humans and guinea pigs, its existence in mice and interaction with ultrasound within the hearing range remain unknown. In this study, we found that ultrasound above the hearing range delivered through the temporal bone evokes the cochlear microphonic potential (CM) in mice. The CM synchronized with the applied single-tone ultrasound, and was actively amplified. Furthermore, the amplitudes of the CM were suppressed by sound with subharmonic frequencies of the applied frequencies. The results indicate that hair cells in mice can detect ultrasound stimuli with frequencies over 120 kHz and ultrasounds within and above the hearing range evoked hair cell currents at the close position along the cochlea.

Indexed as

Cochlear Microphonic PotentialsHearingUltrasonic WavesAcoustic StimulationAnimalsCochleaHair Cells, AuditoryMaleMiceauditory brainstem responsecochlear microphonic potentialharmonics detectionultrasonic hearing

Identifiers

PMID39988786
PMCPMC12314633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.