Evidence map›Paper›PMID 39988785›Full record

ArticleThe American journal of bioethics : AJOB2025

Building Better Medicine: Translational Justice and the Quest for Equity in US Healthcare.

Megan A Allyse, Preya Agam, Yvonne Bombard, Roel Feys, McKenna Horstmann, Assata Kokayi, Rosario Isasi, Karen M Meagher, Marsha Michie, Kiran Musunuru and 3 more

Abstract read
In one paragraph

Article in The American journal of bioethics : AJOB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
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  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Megan A AllyseMayo Clinic.ORCID 0000-0001-6136-9256
Preya AgamMayo Clinic.ORCID 0009-0007-1402-7422
Yvonne BombardUniversity of Toronto.ORCID 0000-0002-9516-4539
Roel FeysUniversity of Miami.ORCID 0009-0006-0990-477X
McKenna HorstmannCase Western Reserve University.ORCID 0009-0002-5518-3468
Assata KokayiMayo Clinic.ORCID 0009-0002-6520-6168
Rosario IsasiUniversity of Miami.ORCID 0000-0002-4937-7007
Karen M MeagherMayo Clinic.ORCID 0000-0002-1055-6091
Marsha MichieCase Western Reserve University.ORCID 0000-0001-6631-828X
Kiran MusunuruUniversity of Pennsylvania.ORCID 0000-0003-3298-0368
Kelly E OrmondETH Zurich.ORCID 0000-0002-1033-0818
Kirsten A RigganETH Zurich.ORCID 0000-0002-0127-9555
Jane Q YapMayo Clinic.ORCID 0009-0004-8189-0208

Funding

PaSAGE: PAtient Supported Approaches to Gene EditingR01HG011461 · NHGRI · MAYO CLINIC JACKSONVILLE · PI ALLYSE, MEGAN A., ISASI, ROSARIO · 2022 to 2024
$2.4M
NHGRI NIH HHS R01 HG011461
6 · The paper itself

Abstract

Despite considerable scientific progress and the evolution of regulatory pathways to ensure safety and efficacy, US healthcare continues to see increasing health disparities. This suggests that clinical translation in of itself cannot be the only measure of its own success, especially when the most marginalized patients, are neglected in the development and implementation of medical innovations. This raises the question of whether a system that is narrowly focused on technical achievement can meet the moral obligations of medicine and public health. We argue that traditional technocratic standards are failing to integrate normative considerations into biomedical translation. What is needed is a translational domain that moves beyond safety and efficacy toward anticipating how proposed technologies will be effective in society as it exists. We propose an additional metric of success: translational justice.

Indexed as

Delivery of Health CareHealthcare DisparitiesHealth EquitySocial JusticeTranslational Research, BiomedicalHumansMoral ObligationsPublic HealthUnited Statesbiomedical researchclinical translationhealth justice

Identifiers

PMID39988785
PMCPMC12143965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.