Observational studyWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Comparison of energy expenditure with level of amputation in patients with diabetes mellitus.
Observational study in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming.Frontiers in pharmacology · 2025Article
- Comparison of energy expenditure with level of amputation in patients with diabetes mellitus.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Diabetes mellitus (DM) is the leading cause of non-traumatic lower extremity amputations in the USA. After these amputations, patients exhibit reduced mobility and increased energy demands of walking. The best surgical practice is to preserve as much of a functional limb as possible, in part due to the fact that proximal amputations result in a greater increase in energy expenditure compared to more distal amputations. While differences in transfemoral, transtibial and partial foot amputation levels have been previously documented, no studies have directly compared transtibial and transmetatarsal amputees. The present study aimed to compare energy expenditure and patient-reported outcomes in patients with diabetes mellitus who have undergone transmetatrsal (TMA) and transtibial amputations (TTA). Thirty-nine DM participants with either unilateral TMA, unilateral TTA or no amputations (control group) participated in this observational study. Energy expenditure, heart rate (HR) and distance travelled during six-minute walk test (6MWT), the Foot and Ankle Ability Measure (FAAM) and the Patient-Reported Outcomes Measurement Information System (PROMIS-29) were measured at a single research visit. No significant differences between the three groups were detected in energy expenditure, HR or distance covered during 6MWT, as well as in PROMIS-29 or FAAM patient-reported outcomes. While the results of this study suggest no differences in functional and patient-reported outcomes between transmetatarsal and transtibial amputees, a larger sample size that would allow for control of comorbidities is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.