Evidence map›Paper›PMID 39988696›Full record

ArticleOncogene2025

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.

Zenghua Sheng, Shu Luo, Lan Huang, Ya-Nan Deng, Nan Zhang, Yinheng Luo, Xinyu Zhao, Ying Chen, Qiu Li, Ruiwu Dai and 1 more

Abstract read
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Phosphoprotein Profile of Ameloblastoma.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zenghua Sheng *Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.ORCID http://orcid.org/0000-0003-1834-3733
Shu Luo *Department of Medical Oncology, Suining First People's Hospital, Suining, Sichuan, PR China.
Lan Huang *Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Ya-Nan DengDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Nan ZhangDepartment of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, PR China.
Yinheng LuoDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Xinyu ZhaoDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Ying ChenDepartment of Medical Oncology, Suining First People's Hospital, Suining, Sichuan, PR China.
Qiu LiDepartment of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, PR China.
Ruiwu DaiDepartment of General Surgery, General Hospital of Western Theater Command, Chengdu, PR China.ORCID http://orcid.org/0000-0002-5487-135X
Shufang LiangDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, PR China. zizi2006@scu.edu.cn.ORCID http://orcid.org/0000-0003-1000-7508

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31961143005
6 · The paper itself

Abstract

Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex by employing protein co-immunoprecipitation enrichment in combination with His

Indexed as

Colorectal NeoplasmsCysteine EndopeptidasesProto-Oncogene Proteins c-aktY-Box-Binding Protein 1AnimalsCell Line, TumorCell MovementCell ProliferationDEAD-box RNA HelicasesHumansMiceSignal TransductionSumoylationCysteine EndopeptidasesDdx5 protein, humanDEAD-box RNA HelicasesProto-Oncogene Proteins c-aktSENP1 protein, humanY-Box-Binding Protein 1YBX1 protein, human

Identifiers

PMID39988696
PMCPMC12052596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.