Evidence map›Paper›PMID 39988622›Full record

ArticleJournal of molecular neuroscience : MN2025

Effect of Interaction of ATG7 and Plasma Metal Concentrations on Cognitive Impairment in Rural China.

Xu Tang, Jiejing Cao, Jiansheng Cai, Xiaoting Mo, Yanfei Wei, Kailian He, Zeyan Ye, Yu Jian Liang, Linhai Zhao, Lidong Qin and 3 more

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xu Tang *Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Jiejing Cao *Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Jiansheng CaiDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Xiaoting MoDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Yanfei WeiDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Kailian HeSchool of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guangxi Zhuang Autonomous Region, Guilin, China.
Zeyan YeSchool of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guangxi Zhuang Autonomous Region, Guilin, China.
Yu Jian LiangDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Linhai ZhaoDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Lidong QinDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
You LiSchool of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guangxi Zhuang Autonomous Region, Guilin, China.
Jian QinDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China.
Zhiyong ZhangDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, 530021, China. rpazz@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study is to explore the association of plasma metal concentrations with impaired cognitive function in different genotypes of ATG7 using multiple models. A cross-sectional survey was conducted in rural China among 994 individuals aged 30 years or older. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Genetic analysis focused on two single-nucleotide polymorphisms (SNPs) in the autophagy-related gene ATG7 (rs2606757 and rs8154). Plasma concentrations of metals were quantified using inductively coupled plasma mass spectrometry. Restricted cubic splines were used to explore the association between serum metal concentration and the occurrence of mild cognitive impairment in individuals with various genotypes. Bayesian Kernel Machine Regression (BKMR) models were used to explore the interactions between individual metals. In a restricted cubic spline model, there is a nonlinear relationship between plasma concentration of Cd and the occurrence of cognitive impairment in individuals carrying the AA (P of Nonlinear = 0.008) and AT (P of Nonlinear = 0.007) genotypes at the rs2606757. However, in people carrying the TT genotype at the rs2606757 locus, the concentration of metals in plasma was not significantly associated with cognitive impairment (P of Nonlinear = 0.534). The results of the BKMR model are consistent with those of the restricted cubic spline model. The TT genotype at rs2606757 in ATG7 appears to confer greater cognitive resilience against Cd-induced cognitive damage. These findings highlight the importance of considering gene-environment interactions in the context of cognitive impairment and suggest potential avenues for preventing cognitive decline in individuals exposed to Cd. Further research is needed to elucidate the precise mechanisms underlying these interactions.

Indexed as

Autophagy-Related Protein 7Cognitive DysfunctionMetalsAdultAgedChinaFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideATG7 protein, humanAutophagy-Related Protein 7MetalsATG7BKMRCognitive impairmentPlasma metals

Identifiers

PMID39988622

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.