Evidence map›Paper›PMID 39988613›Full record

ArticleNature communications2025

Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.

Zhiyuan Guo, Shuang Liu, Bing Zhou, Junqi Liu, Haiyang Wang, Yifei Pi, Xiaoyan Wang, Yingyi Mo, Bo Guo, Jianfei Hua and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhiyuan Guo *Department of Engineering Physics, Tsinghua University, Beijing, China.ORCID http://orcid.org/0009-0005-0501-6479
Shuang Liu *Department of Engineering Physics, Tsinghua University, Beijing, China.
Bing Zhou *Department of Engineering Physics, Tsinghua University, Beijing, China.
Junqi Liu *Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haiyang Wang *Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yifei PiDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoyan WangDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yingyi MoDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bo GuoBeijing Academy of Quantum Information Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-1441-1428
Jianfei HuaDepartment of Engineering Physics, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-9708-652X
Yang WanDepartment of Engineering Physics, Tsinghua University, Beijing, China. yangwan23@zzu.edu.cn.ORCID http://orcid.org/0000-0001-6089-3718
Wei LuDepartment of Engineering Physics, Tsinghua University, Beijing, China. weilu@ihep.ac.cn.ORCID http://orcid.org/0000-0002-5435-3130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and easy manipulation by magnetic components. One promising approach to compactly delivering these high energy electron beams in a cost-effective manner is laser wakefield acceleration (LWFA), which offers ultra-strong accelerating gradients. However, the transition from this concept to a functional machine intended for tumor treatment remains elusive. Here we present the self-developed pro- totype for LWFA-based VHEE radiotherapy, exhibiting compactness (occupying less than 5 m

Indexed as

ElectronsLasersNeoplasmsRadiotherapy, High-EnergyAnimalsCell Line, TumorFemaleHumansMiceRadiotherapy Dosage

Identifiers

PMID39988613
PMCPMC11847918

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.