Evidence map›Paper›PMID 39988579›Full record

ArticleNPJ vaccines2025

Functionality and translation fidelity characterization of mRNA vaccines using platform based mass spectrometry detection.

Alyssa Q Stiving, Benjamin W Roose, Christopher Tubbs, Mark Haverick, Ashley Gruber, Richard R Rustandi, Jesse Kuiper, Matthew Schombs, Hillary Schuessler, Xuanwen Li

Abstract read
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Recoding by NNature communications · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alyssa Q Stiving *Analytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA. alyssa.stiving@merck.com.ORCID http://orcid.org/0000-0002-9334-1212
Benjamin W Roose *Analytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Christopher TubbsAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Mark HaverickAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Ashley GruberAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Richard R RustandiAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Jesse KuiperAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Matthew SchombsAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Hillary SchuesslerAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA.
Xuanwen LiAnalytical Research & Development, Merck & Co., Inc, 126 E Lincoln Ave., Rahway, NJ, USA. xuanwen.li@merck.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The success of mRNA-based therapeutics and vaccines is attributed to their rapid development, adaptability, and scalable production. Modified ribonucleotides like N

Identifiers

PMID39988579
PMCPMC11847942

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.