Evidence map›Paper›PMID 39988489›Full record

ArticleResearch in social & administrative pharmacy : RSAP2025

Design and implementation of a risk-adapted, longitudinal, theory-driven medication adherence intervention: A protocol for a multi-phasic, hybrid effectiveness-implementation trial.

Benyam Muluneh, Maurlia Upchurch, Bethel Belayneh, Emily Mackler, Ashley Leak Bryant, William A Wood, Marcella H Boynton, Stephanie B Wheeler, Leah L Zullig, Jennifer Elston Lafata

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in social & administrative pharmacy : RSAP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benyam MulunehDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA. Electronic address: bmuluneh@unc.edu.
Maurlia UpchurchDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Bethel BelaynehDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Emily MacklerMichigan Oncology Quality Consortium, Ann Arbor, MI, USA.
Ashley Leak BryantLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA; School of Nursing, University of North Carolina at Chapel Hill, USA.
William A WoodLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA; School of Medicine, University of North Carolina at Chapel Hill, USA.
Marcella H BoyntonSchool of Medicine, University of North Carolina at Chapel Hill, USA.
Stephanie B WheelerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA; Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
Leah L ZulligDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, Durham, NC, USA.
Jennifer Elston LafataLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA; Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.

Funding

North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Design and implementation of a social cognitive theory-based medication adherence coaching interventionK08CA279500 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Benyam Muluneh · 2023 to 2026
$776k
NCATS NIH HHS KL2 TR002490NCI NIH HHS K08 CA279500
6 · The paper itself

Abstract

backgroundThe increasing use of targeted oral anticancer agents (OAAs) has transformed cancer treatment, yet patient adherence in real-world settings remains suboptimal. This protocol outlines a multi-phasic, hybrid effectiveness-implementation trial designed to develop, implement, and evaluate a risk-adapted, longitudinal medication adherence intervention for patients prescribed OAAs.

methodsDrawing on social cognitive theory, intervention mapping, and implementation science, the study aims to address barriers at cognitive, behavioral, and environmental levels that impact adherence. Phase 1 identifies implementation barriers and refines strategies, informed by expert input and semi-structured interviews. Phase 2 incorporates patient-centered feedback to tailor a theory-driven intervention targeting adherence barriers. In Phase 3, the intervention is piloted across diverse clinical settings to assess its effectiveness and implementation feasibility.

conclusionThis trial aims to deliver a scalable and sustainable model for adherence support, with broad implications for improving patient outcomes and integrating adherence monitoring in routine cancer care.

Indexed as

Antineoplastic AgentsMedication AdherenceNeoplasmsAdherence InterventionsAdministration, OralClinical Trials as TopicHumansLongitudinal StudiesResearch DesignAntineoplastic Agents

Identifiers

PMID39988489
PMCPMC11911068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.