ArticleMucosal immunology2025
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice.
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Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
8 citing papers in PubMed.
- Crohn's Disease: From Immune Dysregulation to Intestinal Damage.Inflammation · 2026Review
- Distinct immunological signatures in autoimmunity: a multi-plex analysis for the differential diagnosis of established and undifferentiated autoimmune diseases (a cross-sectional pilot study).Rheumatology international · 2026Article
- DsbA-L safeguards T cell mitochondrial redox homeostasis to restrain Th17 differentiation and colitis.Cell death & disease · 2026Article
- Review
- Prolonged Wnt3a exposure tolerizes macrophages to inflammatory stimuli.Frontiers in immunology · 2026Article
- Trained Immunity in Bladder ILC3s Enhances Mucosal Defense Against Recurrent Urinary Tract Infections.Biomedicines · 2025Article
- Fundamental and emerging insights into innate and adaptive immunity in inflammatory bowel diseases.Frontiers in immunology · 2025Review
- Deciphering the immunocellular regulatory network in inflammatory bowel disease: from susceptibility genes to cellular effectors and toward precision therapies.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
23 authors.
Jing LiDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Justin JacobseDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Willem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN USA 37212.
Jennifer M PilatDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Harsimran KaurProgram in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Weihong GuDepartment of Pediatrics, Yale Medical School, New Haven, CT 06520, USA.
Seung Woo KangDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Mark RusznakDepartment of Internal Medicine Vanderbilt University Medical Center, Nashville, TN, USA.
Hsin-I HuangDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Julio BarreraDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Pauline A OlooDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Joseph T RolandDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Internal Medicine Vanderbilt University Medical Center, Nashville, TN, USA.
Caroline V HawkinsDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
Andrew P PahnkeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Marian KhalilDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
M Kay WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.
Keith T WilsonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN USA 37212; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher S WilliamsDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN USA 37212; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.
R Stokes PeeblesDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN USA 37212; Department of Internal Medicine Vanderbilt University Medical Center, Nashville, TN, USA.
Liza KonnikovaDepartment of Pediatrics, Yale Medical School, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA; Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT 06520, USA; Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT 06520, USA; Program in Translational Biomedicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Obstetrics Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA.
Yash A ChoksiDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN USA 37212; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.
Gianna Elena HammerDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA.
Ken S LauProgram in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT 84112, USA; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN, USA.
Jeremy A GoettelDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: jeremy.goettel@vumc.org.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MTuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4MFunction of T cells at the Maternal-Fetal InterfaceR01AI171980 · NIAID · YALE UNIVERSITY · PI Liza Konnikova · 2022 to 2026
$3.5MSpermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisR01DK128200 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2021 to 2024
$2.7MDeciphering Epithelial Signals in the Liver to Drive Inflammation and FibrosisR01DK129552 · NIDDK · YALE UNIVERSITY · PI YIMLAMAI, DEAN · 2021 to 2025
$2.2MLiver-Gut Axis in Neonatal Anemia and Its Role in RBC Transfusion Associated Gut InjuryR01HL163043 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Mohan Kumar Krishnan · 2023 to 2026
$1.9MAPCs and environmental cues for inflammation-linked Th17 immunityR01AI145930 · NIAID · UNIVERSITY OF UTAH · PI HAMMER, GIANNA ELENA · 2020 to 2023
$1.8MInvestigating the Role of IL-23R in Mucosal Regulatory T CellsR03DK123489 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOETTEL, JEREMY ALLEN · 2020 to 2021
$260kBLRD VA I01 BX001426BLRD VA IK2 BX004648CSRD VA I01 CX002473NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA236733NHLBI NIH HHS R01 HL163043NIAID NIH HHS R01 AI145930NIAID NIH HHS R01 AI171980NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK103831NIDDK NIH HHS R01 DK128200NIDDK NIH HHS R01 DK129552NIDDK NIH HHS R03 DK123489NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS S10 OD023475
Abstract
Interleukin-10 (IL-10) is an immunomodulatory cytokine critical for intestinal immune homeostasis. IL-10 is produced by various immune cells but IL-10 receptor signaling in intestinal CX
Indexed as
ColitisImmunity, InnateInterleukin-10Intestinal MucosaLymphocytesAnimalsCX3C Chemokine Receptor 1Disease Models, AnimalInflammationMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3CX3C Chemokine Receptor 1Cx3cr1 protein, mouseIL10 protein, mouseInterleukin-10Nuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mouseCCL26CX(3)CR1IBDIL-10ILC3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.