Evidence map›Paper›PMID 39987980›Full record

ArticleAmerican journal of ophthalmology2025

Hyperreflective Foci Along the Retinal Pigment Epithelium Predict the Onset of Large Choroidal Hypertransmission Defects in Age-Related Macular Degeneration.

Alessandro Berni, James D Kastner, Mengxi Shen, Yuxuan Cheng, Gissel Herrera, Farhan Hiya, Jeremy Liu, Liang Wang, Jianqing Li, Omar S El-Mulki and 7 more

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Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. En face visualization of the outer choroidal vessels in regions with geographic atrophy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review of emerging imaging findings to reveal a broader spectrum of lesions in AMD.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  6. Article
  7. Article
  8. Spatial distribution of Intra-retinal Hyper-reflective foci and impact on progression in eyes with intermediate Age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alessandro BerniFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute (A.B.), Milan, Italy.
James D KastnerFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Mengxi ShenFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Yuxuan ChengDepartment of Bioengineering, University of Washington (Y.C., R.K.W.), Seattle, Washington, USA.
Gissel HerreraFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Farhan HiyaFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Jeremy LiuFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA; Department of Ophthalmology and Visual Science, Yale University School of Medicine (J.Liu), New Haven, Connecticut, USA.
Liang WangFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Jianqing LiFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA; Department of Ophthalmology, First Affiliated Hospital of Soochow University (J.Li), Suzhou, Jiangsu, China.
Omar S El-MulkiFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Sara BeqiriFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Omer TrivizkiFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA; Department of Ophthalmology, Tel Aviv Medical Center, University of Tel Aviv (O.T.), Tel Aviv, Israel.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine (N.K.W.), Boston, Massachusetts, USA.
Robert O'BrienFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Giovanni GregoriFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington (Y.C., R.K.W.), Seattle, Washington, USA; Department of Ophthalmology, University of Washington (R.K.W.), Seattle, Washington, USA.
Philip J RosenfeldFrom the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (A.B., J.D.K., M.S., G.H., F.H., J.Liu, L.W., J.Li, O.S.E.-M., S.B., O.T., R.O., G.G., P.J.R.), Miami, Florida, USA. Electronic address: prosenfeld@miami.edu.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY028753
6 · The paper itself

Abstract

purposeIn eyes with intermediate age-related macular degeneration (iAMD), we separately quantified the hyperreflective foci (HRF) along the retinal pigment epithelium (rpeHRF) and the intraretinal HRF (iHRF) to determine if the location of the HRF predicted the progression from iAMD to the onset of large persistent choroidal hypertransmission defects (hyperTDs).

designPost hoc subgroup cohort analysis of a prospective study.

methodsA retrospective analysis was performed on a prospective natural history database of eyes with AMD imaged using swept-source optical coherence tomography (SS-OCT). En face images derived from choroidal slabs positioned 64 to 400 µm beneath Bruch membrane were used with a semiautomated algorithm to identify and quantify hypotransmission defects (hypoTDs) attributable to either iHRF or rpeHRF within a 5-mm fovea-centered circle. iHRF were identified on corresponding B-scans as hyperreflective lesions within the neurosensory retina, and rpeHRF were identified as areas of retinal pigment epithelium thickening. Multivariable survival analysis was performed to determine if the area measurements of either iHRF or rpeHRF were more likely to predict the onset of the first large persistent hyperTD.

resultsOf the 171 eyes with iAMD included in this study, 82 (48%) developed at least 1 large hyperTD during a median follow-up of 59.1 months. Univariable Cox regression analyses showed that rpeHRF area (P < .001), iHRF area (P = .003), and drusen volume (P < .001) were all significantly associated with the onset of the first large persistent hyperTD. However, a multivariable Cox regression model showed that only the rpeHRF area remained a significant predictor of disease progression (P < .001).

conclusionsIn iAMD eyes, the area of rpeHRF was more predictive of disease progression than either the drusen volume or iHRF, which suggests that these rpeHRF serve as harbingers of focal atrophy formation and may predict where hyperTDs form.

Indexed as

ChoroidChoroid DiseasesMacular DegenerationRetinal Pigment EpitheliumAgedAged, 80 and overDisease ProgressionFemaleFluorescein AngiographyFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRetrospective StudiesTomography, Optical Coherence

Identifiers

PMID39987980
PMCPMC12492339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.