Evidence map›Paper›PMID 39987750›Full record

ArticleUltrasonics sonochemistry2025

Optimization of the effect of cold plasma treatment on UAE-NADES green extraction of chickpea roots (Cicer arietinum) bioactive compounds.

Waseem Khalid, Imed E Benmebarek, Sina Zargarchi, Prashant Kumar, Miral Javed, Andres Moreno, Aanchal Sharma, Gulzar Ahmad Nayik, Tuba Esatbeyoglu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Waseem KhalidDepartment of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla La Mancha, 13071 Ciudad Real, Spain; Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany.
Imed E BenmebarekDepartment of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla La Mancha, 13071 Ciudad Real, Spain.
Sina ZargarchiDepartment of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany.
Prashant KumarDepartment of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany; Department of Chemical Engineering, Indian Institute of Technology, Tirupati, Yerpedu, India.
Miral JavedSchool of Engineering, University of Guelph, Guelph, Canada.
Andres MorenoDepartment of Organic Chemistry, Faculty of Chemical Sciences and Technologies, University of Castilla La Mancha, 13071 Ciudad Real, Spain. Electronic address: andres.moreno@uclm.es.
Aanchal SharmaUniversity Centre for Research and Development, Chandigarh University, Gharuan, Mohali 140413 Punjab, India.
Gulzar Ahmad NayikMarwadi University Research Centre, Department of Microbiology, Marwadi University, Rajkot, Gujarat 360003, India.
Tuba EsatbeyogluDepartment of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany. Electronic address: esatbeyoglu@foh.uni-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chickpea (Cicer arietinum L.) root is an agricultural by-product with the potential for extracting valuable bioactive compounds that often remains underutilized. This study introduces an integrated extraction methodology to enhance the extraction of bioactives using atmospheric air low-pressure cold plasma (CP) treatment followed by ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NADES). Chickpea root powder was first subjected to CP treatment under optimized conditions (power, pressure, and time) identified via response surface methodology (RSM). Subsequently, UAE-NADES extraction was performed to maximize the results of antioxidant activity (DPPH) and total phenolic content (TPC). The integrated CP-UAE-NADES process enhanced TPC and DPPH compared to the untreated sample (non-CP). The optimum conditions were 11.5 min, 52 W, and 0.65 mbar. The predicted values of the Box-Behnken design for TPC and DPPH were compatible with the experimental Furthermore, microbial load reduction and color stability were analyzed to ensure chickpea root quality and functionality. The combined extraction methodology offers a sustainable and eco-friendly approach for the valorization of chickpea root as a source of bioactives, with potential applications in functional foods, nutraceuticals, and pharmaceuticals.

Indexed as

Chemical FractionationCicerPlant RootsPlasma GasesSolventsUltrasonic WavesAntioxidantsPhenolsAntioxidantsPhenolsPlasma GasesSolventsAntimicrobial activityAntioxidant activityBiomassNon-thermal treatmentPolyphenolUltrasound

Identifiers

PMID39987750
PMCPMC11894318

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.