ArticleBMC oral health2025
Patterns of lymph node metastasis and treatment outcomes of parotid gland malignancies.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Treatment Outcomes of Total Versus Superficial Parotidectomy With Postoperative Radiotherapy for High-Grade Parotid Carcinoma Confined to the Superficial Lobe: A Propensity Score-Adjusted Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Observational
- [Neck dissection-more, less, targeted?]HNO · 2026Review
- Clinicopathologic Features and Postoperative Outcomes of Parotidectomy: A 16-Year Retrospective Cohort Study from a Tertiary Referral Center.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound-Based Deep Learning Radiomics to Predict Cervical Lymph Node Metastasis in Major Salivary Gland Carcinomas.International dental journal · 2025Article
- Feasibility of Lower Neck Sparing in Postoperative Radiotherapy for Parotid Gland Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to characterize the pattern of cervical lymph node spread and evaluate prognostic factors and outcomes of surgery and postoperative adjuvant therapy in primary parotid carcinoma (PPC).
methodsWe retrospectively enrolled 136 patients with PPC. The primary outcomes were disease-free survival (DFS) and overall survival (OS). We used Cox hazards models to assess variables influencing survival, and chi-square tests and logistic regression models to evaluate correlations between pN + and clinicopathological factors.
resultsPathology-confirmed lymph node metastasis was detected in 60.0% and 84.1% of the patients with cT1-2 and cT3-4 tumors, respectively. The occult metastasis rate in cN0 was 55.2%. Level II metastasis was most common (93.2%), followed by level I (49.3%). Histological type, histologic grade, pT stage, and AJCC stage were significant risk factors for lymph node metastasis. One- and five-year OS were 86.0% and 49.3%, respectively (median, 60 months) and 71.6% and 34.8%, respectively, for DFS (median, 24 months). Surgery with
conclusionHistological high grade and advanced T classification were associated with occult lymph node metastasis. Postoperative radiotherapy (RT)/radiochemotherapy (RCT), conferred significant survival benefits in PPC. Neck dissection in patients with cN0 cancer significantly improved DFS and should be performed on those with high-grade and/or advanced T-stage tumors.
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