ArticleArchives of dermatological research2025
Association of environmental phenol and paraben exposure with allergic biomarkers in eczema: findings from NHANES 2005-2006.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Exposure to Urinary and Dust Parabens: Compound-Specific Risks for Pediatric Respiratory Allergic Phenotypes.Toxics · 2026Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-disrupting chemicals such as phenols and parabens can promote allergic conditions including eczema. We aimed to analyze the association between exposure to environmental phenols and parabens and allergic biomarkers-including total serum Immunoglobulin E (IgE), C-reactive protein (CRP), and eosinophils-in individuals with eczema, using the dataset from NHANES 2005-2006. This analysis was based on urinary biomarker levels of phenols and parabens, including bisphenol A, benzophenone-3, 4-tert-octylphenol, triclosan, as well as methyl, ethyl, propyl, and butyl parabens. The urinary biomarkers of phenols and parabens were quantified using online SPE-HPLC-MS/MS, while IgE, CRP, and eosinophil levels were analyzed using fluorescent-enzyme immunoassay, the ImmunoCAP 1000 system, latex-enhanced nephelometry, and the Beckman Coulter method, respectively. Following data extraction, we obtained 159 individuals with a history of eczema and categorized them by age for analysis. Our findings showed positive correlations between bisphenol A, triclosan, butyl paraben, methyl paraben, and propyl paraben and allergic biomarkers in children with eczema aged 6 to 8 years. Notably, a significant positive correlation was observed between methyl paraben exposure and IgE levels. In adults with eczema, 4-tert-octylphenol demonstrated a significant positive association with both IgE levels and eosinophil counts. These findings suggest that exposure to these chemicals may exacerbate eczema symptoms.
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