Evidence map›Paper›PMID 39987385›Full record

ArticleAnnals of surgical oncology2025

Neuropathic Pain Following Surgery for Malignant Peripheral Nerve Sheath Tumors.

Floris V Raasveld, Tareq Hanna, Fernando J Pacheco, Marcos R Gonzalez, Benjamin Johnston, Santiago A Lozano-Calderón, Ian L Valerio, Kyle R Eberlin

Abstract read
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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Floris V RaasveldDivision of Plastic and Reconstructive Surgery, Department of General Surgery, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Tareq HannaHand and Arm Center, Department of Orthopedics Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Fernando J PachecoHand and Arm Center, Department of Orthopedics Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marcos R GonzalezDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin JohnstonDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Santiago A Lozano-CalderónDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ian L ValerioDivision of Plastic and Reconstructive Surgery, Department of General Surgery, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Kyle R EberlinDivision of Plastic and Reconstructive Surgery, Department of General Surgery, Massachusetts General Hospital, Harvard University, Boston, MA, USA. keberlin@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that pose significant challenges in surgical management. This study aims to examine the anatomic distribution of MPNSTs, analyze survival rates and predictive factors for survival, and investigate the prevalence of neuropathic pain in patients who have undergone MPNST resection. PATIENTS AND

methodsA retrospective analysis of 119 patients who underwent MPNST resection was conducted. Additionally, a cross-sectional survey was administered and completed by 39 surviving patients to assess neuropathic pain prevalence using the NRS (0-10 scale) and the s-DN4 questionnaire, and quality of life (QoL) using the EQ-5D-5L index (0-1 scale).

resultsMPNSTs most commonly occurred in the lower extremity (42.9%), followed by the upper extremity (21.0%), trunk (19.3%), head and neck (11.8%), and pelvis (5.0%). Female sex (OR: 0.25, 95% CI: 0.10-0.61) and absence of metastases (OR: 0.15, 95% CI: 0.05-0.52) were significantly associated with lower odds of mortality. Among survey respondents, 82.1% reported neuropathic pain following MPNST resection. The patients reported a mean EQ-5D-5L index score of 0.566 (± 0.253) as compared with an EQ-5D-5L of 0.851 (± 0.205) for the US general population.

conclusionsThe high prevalence of neuropathic pain following MPNST resection and its significant impact on QoL highlights the need for improved pain management strategies. Nerve-sparing and/or nerve-reconstructive techniques during or after tumor resection should be considered. Future research should focus on identifying risk factors for neuropathic pain development and evaluating the efficacy of preventive measures to improve long-term pain outcomes for surviving patients with MPNST.

Indexed as

Nerve Sheath NeoplasmsNeuralgiaPostoperative ComplicationsQuality of LifeAdultAgedCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateYoung AdultEn bloc excisionMalignant peripheral nerve sheath tumorNeuropathic painSurvivalTargeted muscle reinnervation

Identifiers

PMID39987385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.